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The 2-year efficacy and safety of iptacopan monotherapy in patients with paroxysmal nocturnal hemoglobinuria with a history of aplastic anemia on concomitant immunosuppressive therapy who entered the roll-over extension program2025 Blood conference-abstract Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Anna Gayà, Morag Griffin, Bing Han, Austin Gladston Kulasekararaj, Jaroslaw Pawel Maciejewski, +11 more
0citations -
Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria2021 New England Journal of Medicine article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Peter Hillmen, Jeff Szer, Ilene Ceil Weitz, Alexander Röth, Britta Höchsmann, Jens Panse, +11 more
407citations -
Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs2023 Blood article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Saskia van der Velden, Thijs L. J. van Osch, Amina Seghier, Arthur E. H. Bentlage, Juk Yee Mok, Dionne M. Geerdes, +9 more
51citations -
Oral Monotherapy with Iptacopan, a Proximal Complement Inhibitor of Factor B, Has Superior Efficacy to Intravenous Terminal Complement Inhibition with Standard of Care Eculizumab or Ravulizumab and Favorable Safety in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia: Results from the Randomized, Active-Comparator-Controlled, Open-Label, Multicenter, Phase III Apply-PNH Study
Régis Peffault de Latour, Alexander Roeth, Austin Gladston Kulasekararaj, Phillip Scheinberg, Yasutaka Ueda, Carlos M. de Castro, +15 more
23citations -
Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens2025 Annals of the Rheumatic Diseases article Immunology and Microbiology Complement system in diseases Open access
Haiyu Wang, Rick J. Groenland, Stef van der Meulen, Hanneke Kapsenberg, Christoph Gstöttner, Elena Domínguez‐Vega, +5 more
10citations -
Efficacy, Safety, and Quality of Life of Pegcetacoplan in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria Treated within the Phase 3 PEGASUS Trial2024 Acta Haematologica article Immunology and Microbiology Complement system in diseases Open access
Hisakazu Nishimori, Hideyuki Nakazawa, Shinobu Tamura, Toshiki Uchida, Kensuke Usuki, Johan Szamosi, +3 more
4citations -
P828: NORMALIZATION OF HEMATOLOGIC AND HEALTH-RELATED QUALITY OF LIFE MARKERS IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA TREATED WITH PEGCETACOPLAN AND BASELINE HEMOGLOBIN AT OR ABOVE 10 G/DL
Jens Panse, Nicolas Daguindau, Sonia Okuyama, Régis Peffault de Latour, Philippe Schafhausen, Nicole Straetmans, +4 more
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Patient-Reported Outcomes: Danicopan As Add-on Therapy to Ravulizumab or Eculizumab Versus Placebo in Patients with Paroxysmal Nocturnal Hemoglobinuria and Clinically Significant Extravascular Hemolysis2023 Blood conference-abstract Immunology and Microbiology Complement system in diseases Open access
Caroline Irene Piatek, Jong Wook Lee, Morag Griffin, Jun‐ichi Nishimura, Christopher Jordan Patriquin, Hubert Schrezenmeier, +9 more
0citations -
Patient-Reported Outcomes (PROs) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 and COMMODORE 1 Trials
Jens Panse, Jaroslav Čermák, Olena Kyselova, Akihiko Gotoh, Fahri Şahin, Hubert Schrezenmeier, +3 more
4citations -
Effect of prednisolone on live birth rate in women with unexplained recurrent pregnancy loss: a study protocol for a double-blind, placebo-controlled, multicentre, randomised controlled trial (PREMI-study)
Yentl Louise Betty Nel Béquet, Marie‐Louise van der Hoorn, Michael Eikmans, Renate G.V.D. Molen, Saskia le Cessie, Nan van Geloven, +15 more
3citations