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Apical tubular complement activation and the loss of kidney function in proteinuric kidney diseases2024 Clinical Kidney Journal article Immunology and Microbiology Complement system in diseases Open access
Firas Farisi Alkaff, Rosa G. M. Lammerts, Mohamed R. Daha, Stefan P. Berger, Jacob van den Born
12citations -
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains2023 Nature Communications article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents
Leoni Abendstein, Douwe J. Dijkstra, Rayman T.N. Tjokrodirijo, Peter A. van Veelen, Leendert Adrianus Trouw, Paul J. Hensbergen, +1 more
50citations -
Expert guidance on when to screen, monitor, and initiate complement inhibition therapy in patients without classical PNH2026 Blood Red Cells & Iron article Immunology and Microbiology Complement system in diseases Open access
Vinod A. Pullarkat, Daria V. Babushok, Carlos M. de Castro, David Dingli, Jamie Lynn Koprivnikar, Jaroslaw Pawel Maciejewski, +8 more
0citations -
Phase 3 randomized COMMODORE 1 trial: Crovalimab versus eculizumab in complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria2024 American Journal of Hematology article Immunology and Microbiology Complement system in diseases Open access
Phillip Scheinberg, Diego V. Clé, Jin Seok Kim, Erfan Nur, Mustafa Nuri Yenerel, Wilma Barcellini, +15 more
52citations -
S183: PHASE III RANDOMIZED, MULTICENTER, OPEN-LABEL COMMODORE 1 TRIAL: COMPARISON OF CROVALIMAB VS ECULIZUMAB IN COMPLEMENT INHIBITOR-EXPERIENCED PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
Phillip Scheinberg, Diego V. Clé, Valentina Giai, Marek Hus, Jin Seok Kim, Cristina Barrenetxea Lekue, +11 more
5citations -
Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP2025 Molecular & Cellular Proteomics article Immunology and Microbiology Complement system in diseases Open access
Tereza Kadavá, Jürgen Strasser, Maryam Marefat, Victor C. Yin, Johannes Preiner, Leendert Adrianus Trouw, +1 more
4citations -
Improvements in hematologic markers and decreases in fatigue with pegcetacoplan for patients with paroxysmal nocturnal hemoglobinuria and mild or moderate anemia (hemoglobin ≥10 g/dL) who had received eculizumab or were naive to complement inhibitors
Jens Panse, Nicolas Daguindau, Sonia Okuyama, Régis Peffault de Latour, Philippe Schafhausen, Nicole Straetmans, +3 more
3citations -
Oral iptacopan monotherapy in paroxysmal nocturnal haemoglobinuria: final 48-week results from the open-label, randomised, phase 3 APPLY-PNH trial in anti-C5-treated patients and the open-label, single-arm, phase 3 APPOINT-PNH trial in patients previously untreated with complement inhibitors2025 The Lancet Haematology article Immunology and Microbiology Complement system in diseases Open access
Antonio Maria Risitano, Austin Gladston Kulasekararaj, Phillip Scheinberg, Alexander Röth, Bing Han, Jaroslaw Pawel Maciejewski, +47 more
15citations -
The role of complement activation in autoimmune liver disease2020 Autoimmunity Reviews article Medicine Liver Diseases and Immunity Open access cited by 1 patent
Maaike Biewenga, Arantza Fariña Sarasqueta, Maarten E. Tushuizen, Eveline S. M. de Jonge‐Muller, Bart van Hoek, Leendert Adrianus Trouw
35citations -
Complement Activation Levels Are Related to Disease Stage in AMD2020 Investigative Ophthalmology & Visual Science article Medicine Retinal Diseases and Treatments Open access cited by 1 patent
Thomas J. Heesterbeek, Yara T. E. Lechanteur, Laura Lorés‐Motta, Tina Schick, Mohamed R. Daha, Lebriz Altay, +6 more
79citations -
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein2024 Proceedings of the National Academy of Sciences article Immunology and Microbiology Biomarkers in Disease Mechanisms Open access cited by 2 patents
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, +4 more
26citations -
P774: SUBSTANTIAL INCREASES IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) RED BLOOD CELL CLONE SIZE WITH ORAL IPTACOPAN MONOTHERAPY CONFIRMS CONTROL OF HEMOLYSIS IN COMPLEMENT INHIBITOR-NAÏVE PNH PATIENTS
Régis Peffault de Latour, Bing Han, Jaroslaw Pawel Maciejewski, Yutaka Ueda, Rong Fu, Li Zhang, +15 more
3citations -
Development of an in vitro system and model-based translational framework to assess haemolysis risk following intravenous abuse of medications containing polyethylene oxide2020 Toxicology in Vitro article Immunology and Microbiology Complement system in diseases Open access
Peter Persich, Gerwin Erik Engels, Willem van Oeveren, Eric Galia, Stephan Benay, Susanne Thun
5citations -
Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein19citations
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The INCLUSIVE System: A General Framework for Adaptive Industrial Automation2020 IEEE Transactions on Automation Science and Engineering article Psychology Human-Automation Interaction and Safety Open access cited by 1 patent
Valeria Villani, Lorenzo Sabattini, Paulina Barańska, Enrico Callegati, Julia N. Czerniak, Adel Debbache, +14 more
31citations