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POS0669 TAPERING SUBCUTANEOUS METHOTREXATE CAUSES MORE DISEASE FLARES COMPARED TO ORAL ADMINISTRATION IN ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS.2022 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
Agnes E. M. Looijen, Elise van Mulligen, A. van der Helm-van Mil, P. De Jong
0citations -
SAT0158 EFFICACY AND SAFETY OF FILGOTINIB IN METHOTREXATE-NAÏVE PATIENTS WITH RHEUMATOID ARTHRITIS: FINCH 3 52-WEEK RESULTS2020 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
René Westhovens, WFC Rigby, Désirée van der Heijde, William Stohl, Jonathan Kay, A Chopra, +11 more
8citations -
THU0194 CHARACTERISATION OF DEPTH OF RESPONSE, INCLUDING 50% IMPROVEMENT IN ACR COMPONENTS AT WEEK 12 AND REMISSION AT WEEK 24, FOLLOWING TREATMENT WITH FILGOTINIB COMPARED WITH METHOTREXATE OR ADALIMUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS2020 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies
Gerd Rüdiger Burmester, Daniel Aletaha, Janet Elizabeth Pope, Yoshiya Tanaka, Patrick Durez, A. Gómez-Centeno, +7 more
0citations -
Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial
Doortje I Krijbolder, Marloes Verstappen, Bastiaan T van Dijk, Yousra J. Dakkak, Leonie E. Burgers, Aleid C. Boer, +10 more
183citations -
Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate2022 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Karel H. van der Pol, Marga Nijenhuis, Bianca Soree, Nienke J. de Boer‐Veger, Anne Marie Buunk, Henk‐Jan Guchelaar, +9 more
37citations -
Development of rheumatoid arthritis after methotrexate in anticitrullinated protein antibody-negative people with clinically suspect arthralgia at risk of rheumatoid arthritis: 4-year data from the TREAT EARLIER trial2024 The Lancet Rheumatology article Medicine Rheumatoid Arthritis Research and Therapies Open access
Quirine A Dumoulin, Doortje I Krijbolder, Leroy R. Lard, Annette H M van der Helm–van Mil
21citations -
THU0198 EFFICACY AND SAFETY OF FILGOTINIB FOR PATIENTS WITH RHEUMATOID ARTHRITIS WITH INADEQUATE RESPONSE TO METHOTREXATE: FINCH 1 52-WEEK RESULTS2020 Annals of the Rheumatic Diseases article Medicine Rheumatoid Arthritis Research and Therapies Open access
Bernard G Combe, A.J. Kivitz, Yoshiya Tanaka, Désirée van der Heijde, Jesus Abraham Simón Campos, Herbert S. B. Baraf, +13 more
11citations -
Is a 1-year course of methotrexate in patients with arthralgia at-risk for rheumatoid arthritis cost-effective? A cost-effectiveness analysis of the randomised, placebo-controlled TREAT EARLIER trial2024 Annals of the Rheumatic Diseases article Economics, Econometrics and Finance Health Systems, Economic Evaluations, Quality of Life Open access
Elise van Mulligen, Sterre S. Bour, Lucas M. A. Goossens, Pascal H P de Jong, Maureen Rutten‐van Mölken, Annette H M van der Helm–van Mil
8citations -
OP0131 WHAT IS THE EFFECT OF METHOTREXATE ON SEMEN PARAMETERS OF MEN DIAGNOSED WITH IMMUNE-MEDIATED DISEASES? RESULTS OF A PROSPECTIVE COHORT STUDY (iFAME-MTX).2022 Annals of the Rheumatic Diseases conference-abstract Medicine Sperm and Testicular Function Open access
Luis Fernando Pérez-García, E. Röder, R. Van Adrichem, L. J. Kranenburg - van Koppen, E. Zirkzee, M.B. Van Doorn, +2 more
3citations -
POS0570 UNSUPERVISED DEEP-LEARNING IDENTIFIES SIX CLINICAL SUBTYPES OF RHEUMATOID ARTHRITIS AT BASELINE THAT ASSOCIATE WITH METHOTREXATE FAILURE DURING FOLLOW-UP2022 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
Tjardo Daniël Maarseveen, Marc P. Maurits, Tom W. J. Huizinga, Marcel J. T. Reinders, Erik B. van den Akker, Rachel Knevel
3citations -
FRI0128 FILGOTINIB PROVIDED RAPID AND SUSTAINED IMPROVEMENTS IN FUNCTIONAL STATUS, PAIN, HEALTH-RELATED QUALITY OF LIFE, AND FATIGUE IN PATIENTS WITH RHEUMATOID ARTHRITIS AND INADEQUATE RESPONSE TO METHOTREXATE: RESULTS FROM THE FINCH 1 STUDY2020 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
Alan Kivitz, Yoshiya Tanaka, S. Lee, L. Ye, Hao Hu, Robin Besuyen, +1 more
3citations -
FRI0115 FILGOTINIB PROVIDED RAPID AND SUSTAINED IMPROVEMENTS IN FUNCTIONAL STATUS, PAIN, AND HEALTH-RELATED QUALITY OF LIFE, AND REDUCED FATIGUE OVER TIME IN PATIENTS WITH RHEUMATOID ARTHRITIS WHO ARE METHOTREXATE-NAÏVE: RESULTS FROM THE FINCH 3 STUDY2020 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies
Rieke Alten, William F. C. Rigby, Alena Pechonkina, Ken Hasegawa, Thijs K. Hendrikx, Tatsuya Atsumi, +1 more
3citations -
POS0543 MACHINE LEARNING PREDICTS RESPONSE TO METHOTREXATE IN RHEUMATOID ARTHRITIS: RESULTS ON THE ESPOIR, t-REACH AND LEIDEN COHORTS2022 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
Vincent Bouget, J. Duquesne, Paul-Henry Cournède, Bruno Fautrel, Françis Guillemin, P. De Jong, +5 more
2citations -
OP0070 INTERVENTION WITH METHOTREXATE IN ARTHRALGIA AT RISK FOR RHEUMATOID ARTHRITIS TO REDUCE THE DEVELOPMENT OF PERSISTENT ARTHRITIS AND ITS DISEASE BURDEN (TREAT EARLIER): A DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED TRIAL2022 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
Doortje I Krijbolder, Y. Dakkak, L. Burgers, A. Boer, Y. Jung Park, K. Visser, +8 more
2citations -
POS0009 COST-UTILITY ANALYSIS OF THE TREAT EARLIER TRIAL: A ONE YEAR COURSE OF METHOTREXATE IN CLINICALLY SUSPECT ARTHRALGIA PATIENTS IS COST-EFFECTIVE2024 Annals of the Rheumatic Diseases conference-abstract Economics, Econometrics and Finance Health Systems, Economic Evaluations, Quality of Life
Elise van Mulligen, Sterre S. Bour, Pascal H P de Jong, Maureen Rutten‐van Mölken, Annette H M van der Helm–van Mil
2citations -
POS0061 INTERCEPTION OF THE DEVELOPMENT OF RHEUMATOID ARTHRITIS BY A 1-YEAR COURSE OF METHOTREXATE IN ACPA-NEGATIVE ARTHRALGIA PATIENTS AT INCREASED RISK FOR RHEUMATOID ARTHRITIS: 4 YEAR RESULTS OF THE TREAT EARLIER TRIAL2024 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies
Quirine A Dumoulin, Doortje I Krijbolder, K. Visser, Leroy R. Lard, Annette H M van der Helm–van Mil
1citations -
POS0678 CLINICAL OUTCOMES OF METHOTREXATE (MTX)-NAIVE RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) ON FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL INITIALLY ON FIL OR MTX DURING THE PHASE 3 PARENT STUDY (PS)2022 Annals of the Rheumatic Diseases article Medicine Rheumatoid Arthritis Research and Therapies Open access
Daniel Aletaha, René Westhovens, T. Atsumi, Y. Tan, A. Pechonkina, Q. Gong, +3 more
1citations -
POS0704 EFFICACY AND SAFETY OF FILGOTINIB IN PATIENTS WITH INADEQUATE RESPONSE TO METHOTREXATE, WITH 4 OR <4 POOR PROGNOSTIC FACTORS: A POST HOC ANALYSIS OF THE FINCH 1 STUDY2022 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
B. Combe, Y. Tanaka, M. H. Buch, Gerd Rüdiger Burmester, B. Bartok, A. Pechonkina, +5 more
0citations -
HTA402 Is a One-Year Course of Methotrexate in Patients With Arthralgia At-Risk for Rheumatoid Arthritis Cost-Effective? A Cost-Effectiveness Analysis of the Randomized Placebo-Controlled Treat Earlier Trial2024 Value in Health conference-abstract Economics, Econometrics and Finance Health Systems, Economic Evaluations, Quality of Life Open access
Elise van Mulligen, PHP de Jong, Maureen Rutten‐van Mölken, AHM van der Helm-van Mil
0citations -
Long-term durability of a time-limited methotrexate intervention in patients with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative arthralgia at increased risk for rheumatoid arthritis (TREAT EARLIER): 5-year data from a double-blind, randomised, placebo-controlled trial
Elise van Mulligen, Quirine A Dumoulin, Hanna W. van Steenbergen, Doortje I Krijbolder, A Willemien Visser, Stefan Böhringer, +1 more
0citations -
The impact of filgotinib on patient-reported outcomes and health-related quality of life for patients with active rheumatoid arthritis: a post hoc analysis of Phase 3 studies2022 Arthritis Research & Therapy article Medicine Rheumatoid Arthritis Research and Therapies Open access
Clifton O. Bingham, David Walker, Peter T. Nash, Sang Hyuck Lee, Lei Ye, Hao Hu, +2 more
10citations