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Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP102025 European Journal of Medicinal Chemistry article Medicine PARP inhibition in cancer therapy Open access
Juho Alaviuhkola, Maria Giulia Nizi, Chiara Vagaggini, Chiara Sarnari, Barbara E. Lippok, Mirko M. Maksimainen, +8 more
1citations -
Development of high-throughput screening assays for profiling snake venom Phospholipase A 2 activity after high-resolution chromatographic fractionation2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Venomous Animal Envenomation and Studies Open access
Kristina B. M. Still, Julien Slagboom, Sarah Kidwai, Chunfang Xie, Bastiaan Eisses, Freek J. Vonk, +3 more
0citations -
Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation2025 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Chemical Synthesis and Analysis Open access
Edith van der Nol, Nicola Haupt, Benthe A. M. Smit, Martin Andre Hoffmann, Martin S. Engler, Marcus Ludwig, +8 more
0citations -
Discovery and mechanism-guided engineering of BHET hydrolases for improved PET recycling and upcycling2023 Nature Communications article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Anni Li, Yijie Sheng, Haiyang Cui, Minghui Wang, Luxuan Wu, Yibo Song, +3 more
112citations -
CompassR Yields Highly Organic‐Solvent‐Tolerant Enzymes through Recombination of Compatible Substitutions2020 Chemistry - A European Journal article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Haiyang Cui, Karl‐Erich Jaeger, Mehdi D. Davari, Ulrich Schwaneberg
39citations -
Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A42021 ChemCatChem article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Nico D. Fessner, Christopher Grimm, Matic Srdič, Hansjörg Weber, Wolfgang Kroutil, Ulrich Schwaneberg, +1 more
12citations -
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate2022 Gut Microbes article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina Borlandelli, Marissa M. Bivins, Natalie K. Barker, +9 more
43citations -
Metagenomics Combined with Activity-Based Proteomics Point to Gut Bacterial Enzymes that Reactivate Mycophenolate2022 medRxiv preprint Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina Borlandelli, Natalie K. Barker, Alicia A. Sorgen, +8 more
6citations -
Activity-based protein profiling reveals dynamic substrate-specific cellulase secretion by saprotrophic basidiomycetes2022 Biotechnology for Biofuels and Bioproducts article Engineering Biofuel production and bioconversion Open access
Nicholas G. S. McGregor, Casper de Boer, Mikhaaeel Santos, Mireille Haon, David Navarro, Sybrin P. Schröder, +3 more
11citations -
From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling2024 Journal of the American Chemical Society article Chemistry Carbohydrate Chemistry and Synthesis Open access
Marta Artola, Johannes M. F. G. Aerts, Gijsbert A. van der Marel, Carme Rovira, Jeroen D. C. Codée, G.J. Davies, +1 more
26citations -
Pharmacogenetic and drug interaction aspects on ketamine safety in its use as antidepressant ‐ implications for precision dosing in a global perspective2022 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Immaculate Mbongo Langmia, Katja Susanne Just, Sabrina Yamoune, Julian Peter Müller, Julia Stingl
40citations -
Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues2022 PLoS ONE article Biochemistry, Genetics and Molecular Biology Polyamine Metabolism and Applications Open access
Armand W.J.W. Tepper, Gerald Chu, Vincent N. A. Klaren, Jay H. Kalin, Patricia Molina-Ortíz, Antonietta Impagliazzo
7citations -
antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation2025 Nucleic Acids Research article Medicine Microbial Natural Products and Biosynthesis Open access
Kai Blin, Lisa Vader, Judit Szenei, Zachary L. Reitz, Hannah E. Augustijn, José D D Cediel-Becerra, +20 more
719citations -
Diagnosis, Therapy and Follow-Up of Diabetes Mellitus in Children and Adolescents2022 Experimental and Clinical Endocrinology & Diabetes article Medicine Diabetes Management and Research
Martin Holder, Thomas Michael Kapellen, Ralph Ziegler, Jutta Bürger-Büsing, Thomas Danne, Axel Dost, +12 more
3citations