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Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L2023 Scientific Reports article Biochemistry, Genetics and Molecular Biology Genomics and Chromatin Dynamics Open access
Mirna Barsoum, Roksaneh Sayadi-Boroujeni, Alexander T. Stenzel, Philip Bussmann, Juliane Lüscher‐Firzlaff, Bernhard Lüscher
5citations -
Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low‐density lipoprotein receptor knockout mice2024 The Journal of Physiology article Immunology and Microbiology Atherosclerosis and Cardiovascular Diseases Open access
Menno Hoekstra, Olga S.C. Snip, Philip Janusz, Mireia N. A. Bernabé Kleijn, Edward R. Truitt, Benjamin David Sullivan, +3 more
3citations -
CRISPR-Cas knockout of miR21 reduces glioma growth2022 Molecular Therapy — Oncolytics article Biochemistry, Genetics and Molecular Biology MicroRNA in disease regulation Open access
Lisa Nieland, Thomas S. van Solinge, Pike-See Cheah, Liza M. Morsett, Joseph B. El Khoury, Joseph I. Rissman, +4 more
42citations -
CRISPR/Cas9 mediated CXCL4 knockout in human iPS cells of polycythemia vera patient with JAK2 V617F mutation2021 Stem Cell Research article Medicine Myeloproliferative Neoplasms: Diagnosis and Treatment Open access
Janik Boehnke, Salim Atakhanov, Marcelo A. S. Toledo, Herdit M. Schüler, Stephanie Sontag, Nicolas Chatain, +4 more
2citations -
Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma2021 npj Systems Biology and Applications article Chemistry Advanced Proteomics Techniques and Applications Open access
Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David J. Schibli, +6 more
7citations -
Myofibre-specific knockout of TGF-β type I receptors triggers muscle hypertrophy and promotes contraction and oxidative metabolism2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders
Andi Shi, Michèle MG Hillege, Carla Offringa, Gang Wu, Tymour Forouzanfar, Willem M.H. Hoogaars, +2 more
1citations -
T Cell-Mediated Immune Rejection of B2M Knockout Induced Pluripotent Stem Cell (iPSC)-Derived Kidney Organoids2023 Journal of the American Society of Nephrology conference-abstract Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research
Cathelijne W. van den Berg, Lonneke H. Gaykema, Rianne Y. van Nieuwland, Ellen Lievers, Juliette A. de Klerk, Sébastien J. Dumas, +3 more
0citations -
Myofiber-specific knockout of TGF-β type I receptors in mice concurrently drives muscle hypertrophy, oxidative metabolism, and absolute force2026 Communications Biology article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Andi Shi, Michèle MG Hillege, Wendy Noort, Carla Offringa, Gang Wu, Tim Forouzanfar, +3 more
0citations -
Inhibition of pannexin‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice2024 Physiological Reports article Biochemistry, Genetics and Molecular Biology Genetic and Kidney Cyst Diseases Open access
Wouter H. van Megen, Teun J. van Houtert, Caro Bos, Dorien J.M. Peters, Jeroen H. F. de Baaij, Joost G.J. Hoenderop
4citations -
Circumventing IFN-γ induced resistance in ovarian cancer with a double-hit: NKG2A knockout of PRAME-TCR expressing NK cells2026 Journal of Ovarian Research article Immunology and Microbiology Immune Cell Function and Interaction Open access
Els P. van Hees, Oliva W. Rensing, Renate S. Hagedoorn, Cilia R. Pothast, Anne K. Wouters, Rosa A. van Amerongen, +3 more
0citations -
A lipid transfer protein knockout library reveals ORP9-ORP11 dimer mediating PS/PI(4)P exchange at the ER-trans Golgi contact site to promote sphingomyelin synthesis2023 eLife preprint Biochemistry, Genetics and Molecular Biology Lipid metabolism and biosynthesis Open access
Birol Cabukusta, Shalom Borst Pauwels, Jimmy J.L.L. Akkermans, Niek Blomberg, Aat A. Mulder, Roman I. Koning, +2 more
2citations -
Reviewer #2 (Public Review): A lipid transfer protein knockout library reveals ORP9-ORP11 dimer mediating PS/PI(4)P exchange at the ER-trans Golgi contact site to promote sphingomyelin synthesis2023 peer-review Biochemistry, Genetics and Molecular Biology Lipid metabolism and biosynthesis Open access
Birol Cabukusta, Shalom Borst Pauwels, Jimmy J.L.L. Akkermans, Niek Blomberg, Aat A. Mulder, Roman I. Koning, +2 more
0citations -
MoIug4 is a novel secreted effector promoting rice blast by counteracting host OsAHL1‐regulated ethylene gene transcription2022 New Phytologist article Agricultural and Biological Sciences Plant-Microbe Interactions and Immunity Open access
Xinyu Liu, Yixin Gao, Ziqian Guo, Nian Wang, Alex Wegner, Xi Zou, +7 more
27citations -
LXR Agonist T0901317′s Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice
Menno Hoekstra, Laura M. de Jong, Rick van der Geest, Lidewij R. de Leeuw, Rani Krisnamurthi, Janine J. Geerling, +1 more
6citations -
Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 62025 Translational Psychiatry article Biochemistry, Genetics and Molecular Biology Nicotinic Acetylcholine Receptors Study Open access
Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer
7citations -
Linking Altered Neuronal and Synaptic Properties to Nicotinic Receptor Alpha5 Subunit Gene Dysfunction: A Translational Investigation in Rat mPFC and Human Cortical Layer 62024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Nicotinic Acetylcholine Receptors Study Open access
Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer
1citations -
Adult male patient with severe intellectual disability caused by a homozygous mutation in the HNMT gene2020 BMJ Case Reports article Biochemistry, Genetics and Molecular Biology Genetics and Neurodevelopmental Disorders Open access
Willem M. A. Verhoeven, J.I.M. Egger, Paddy K.C. Janssen, Arie van Haeringen
15citations -
Fluid shear stress stimulates ATP release without regulating purinergic gene expression in the renal inner medullary collecting duct2023 The FASEB Journal article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Wouter H. van Megen, Esra Canki, Vera H. A. Wagenaar, Charlotte R. M. M. van Waes, Dorien J.M. Peters, Jenny van der Wijst, +1 more
5citations -
The Brugada syndrome associated gene WT1 impacts on SCN5A expression and cardiac conduction2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cardiac electrophysiology and arrhythmias Open access
E. Madelief Marsman, Joost Allard Offerhaus, Thomas Stervinou, Leander Beekman, Simona Casini, T J Streef, +11 more
0citations -
P-802 Unraveling a distinct role for GATA3 in mouse and human trophectoderm development via CRISPR/Cas9 gene editing2025 Human Reproduction conference-abstract Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Sofie Declercq, Gwenny Cosemans, Tijs Vanhessche, Dominic Stoop, Susana M. Chuva de Sousa Lopes, Kim De Leeneer, +2 more
0citations -
Precise and broad scope genome editing based on high-specificity Cas9 nickases2020 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Qian Wang, Jin Liu, Josephine M. Janssen, Marie Le Bouteiller, Richard L. Frock, Manuel A.F.V. Gonçalves
36citations