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Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice2022 International Journal of Molecular Sciences article Medicine Liver Disease Diagnosis and Treatment Open access
Florine Seidel, Robert Kleemann, Wim van Duyvenvoorde, Nikki van Trigt, Nanda Keijzer, Sandra van der Kooij, +10 more
15citations -
Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators2024 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, +10 more
11citations -
At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity2022 The Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access
Nienke Oskam, Pleuni Ooijevaar‐de Heer, Ninotska I. L. Derksen, Simone Kruithof, Steven W. de Taeye, Gestur Vidarsson, +4 more
27citations -
A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis2022 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Sepsis Diagnosis and Treatment Open access
Feiyan Liu, Linda B. S. Aulin, Sebastiaan S. A. Kossen, Julius Cathalina, Marlotte Bremmer, Amanda C. Foks, +3 more
11citations -
Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target2026 Cell stem cell article Medicine Myeloproliferative Neoplasms: Diagnosis and Treatment Open access
Bérénice Dugué, Pia Wanner, Mayra L. Ruiz Tejada Segura, Mohamed Saad, Lucas Greven, Katrin Götz, +33 more
2citations -
Dysregulated complement activation in COVID-19: The Role of Soluble Complement Inhibitors2026 Clinical & Experimental Immunology article Immunology and Microbiology Complement system in diseases Open access
Stef van der Meulen, Haiyu Wang, Sandrine Nugteren, Frédérique Ponchel, Anna H.E. Roukens, Cilia R. Pothast, +45 more
0citations -
Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus2024 European Journal of Immunology article Medicine Systemic Lupus Erythematosus Research Open access
Stef van der Meulen, Rory Caitlin Monahan, Kyra A. Gelderman, Cees van Kooten, Y K Onno Teng, Tom W. J. Huizinga, +2 more
3citations -
Oral Monotherapy with Iptacopan, a Proximal Complement Inhibitor of Factor B, Has Superior Efficacy to Intravenous Terminal Complement Inhibition with Standard of Care Eculizumab or Ravulizumab and Favorable Safety in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia: Results from the Randomized, Active-Comparator-Controlled, Open-Label, Multicenter, Phase III Apply-PNH Study
Régis Peffault de Latour, Alexander Roeth, Austin Gladston Kulasekararaj, Phillip Scheinberg, Yasutaka Ueda, Carlos M. de Castro, +15 more
23citations -
Balloon cells promote immune system activation in focal cortical dysplasia type 2b2021 Neuropathology and Applied Neurobiology article Medicine Epilepsy research and treatment Open access
Till S. Zimmer, Diede W. M. Broekaart, Mark J. Luinenburg, Caroline Mijnsbergen, Jasper J. Anink, Nam Suk Sim, +11 more
39citations -
Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens2025 Annals of the Rheumatic Diseases article Immunology and Microbiology Complement system in diseases Open access
Haiyu Wang, Rick J. Groenland, Stef van der Meulen, Hanneke Kapsenberg, Christoph Gstöttner, Elena Domínguez‐Vega, +5 more
10citations -
Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity2024 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents
Todor Tschongov, Swagata Konwar, Andreas E Busch, Christian Sievert, Andrea Hartmann, Marina Noris, +7 more
16citations -
Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches2024 Seminars in Immunology article Immunology and Microbiology Complement system in diseases Open access
Vitalijs Ovcinnikovs, Karin Dijkman, Gijs G. Zom, Frank J M Beurskens, Leendert Adrianus Trouw
18citations -
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation2024 Journal of the American Chemical Society article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents
Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman, Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leendert Adrianus Trouw, +1 more
16citations -
Strengthening the WHO Emergency Care Systems Framework: insights from an integrated, patient-centered approach in the Copenhagen Emergency Medical Services system—a qualitative system analysis
Simone Böbel, Jeske Verhoeven, Mirjam Lisa Scholz, Bart Penders, Lorraine Frisina Doetter, Helle Collatz Christensen, +1 more
22citations -
Lectin and alternative complement pathway activation in cutaneous manifestations of IgA-vasculitis: A new target for therapy?2022 Molecular Immunology article Immunology and Microbiology Complement system in diseases Open access
Jeffrey J. Damman, Antien L. Mooyaart, Thierry P. P. van den Bosch, Marc A. Seelen, Martijn B. van Doorn
20citations -
Systemic and local complement activation in peritoneal dialysis patients via conceivably distinct pathways2023 Peritoneal Dialysis International article Immunology and Microbiology Complement system in diseases Open access
Bernardo Faria, Mariana Gaya da Costa, Stefan P. Berger, Carla Lima, Cátia Pêgo, Jacob van den Born, +5 more
1citations