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Combination of vemurafenib with cobimetinib in BRAF V600E/K mutated melanoma patients to normalize LDH and optimize immunotherapy with nivolumab and ipilimumab (COWBOY): A randomized, open-label phase 2 clinical trial.2026 Journal of Clinical Oncology conference-abstract Biochemistry, Genetics and Molecular Biology Melanoma and MAPK Pathways
Anne Sophie Blokland, Rutger H.T. Koornstra, Sofie H. Tolmeijer, Hans M. Westgeest, Marye J. Boers‐Sonderen, Ellen Kapiteijn, +12 more
0citations -
Transcatheter versus surgical aortic valve replacement in low- to intermediate-risk patients: Do DEDICATE trial outcomes translate to real-world populations?2026 Journal of Thoracic and Cardiovascular Surgery article Medicine Cardiac Valve Diseases and Treatments Open access
Edgar J. Daeter, Maaike M. Roefs, R. Post, Jurriën M. ten Berg, Pim A.L. Tonino, Dennis van Veghel, +37 more
0citations -
Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial2020 European Heart Journal article Biochemistry, Genetics and Molecular Biology Connective tissue disorders research Open access
Reza Indrakusuma, Hamid Jalalzadeh, Ron Balm, Janneke Timmermans, Arthur J.H.A. Scholte, Maarten P. van den Berg, +4 more
84citations -
Salpingectomy With Delayed Oophorectomy Versus Salpingo‐Oophorectomy in BRCA1/2 Carriers: Three‐Year Outcomes of a Prospective Preference Trial2025 BJOG An International Journal of Obstetrics & Gynaecology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Majke H.D. van Bommel, Miranda P. Steenbeek, Joanna IntHout, Tessa Van Garderen, Marline G. Harmsen, Angela H.E.M. Maas, +16 more
17citations -
Short-term effects of an elimination diet and healthy diet in children with attention-deficit/hyperactivity disorder: a randomized-controlled trial2023 European Child & Adolescent Psychiatry article Medicine Attention Deficit Hyperactivity Disorder Open access
Annick Bosch, Margreet Bierens, Verena Ly, Jessica van der Velde, Heleen de Boer, Gerry van Beek, +16 more
14citations -
Healthcare Utilization, Costs, and Cost-Effectiveness of Patients Undergoing Laparoscopic and Open Hemihepatectomy: A Secondary Analysis of the ORANGE II PLUS Randomized Controlled, Phase 3, Superiority Trial2025 Annals of Surgical Oncology article Economics, Econometrics and Finance Health Systems, Economic Evaluations, Quality of Life Open access
Bram Olij, Gabriela Pilz da Cunha, Merel Kimman, Francesca Ratti, Mohammad Abu Hilal, Roberto Ivan Troisi, +28 more
2citations -
Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial
Philippe Moreau, Cyrille Hulin, Aurore Perrot, Bertrand Arnulf, Karim Belhadj, Lotfi Benboubker, +46 more
182citations -
Safety and Preliminary Efficacy Results of a Novel Mesenchymal Stromal Cell Therapy in Diabetic Kidney Disease: The Multicenter, Randomized, Placebo-Controlled, Phase-1b/2a NEPHSTROM Clinical Trial2022 Journal of the American Society of Nephrology conference-abstract Medicine Mesenchymal stem cell research
Matthew Dallas Griffin, Giuseppe Remuzzi, Paul Cockwell, Alexander Peter Maxwell, Norberto Perico, Piero Luigi Ruggenenti, +6 more
0citations -
A study protocol for a randomised controlled trial evaluating the safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography only for suspected acute pulmonary embolism in patients with cancer: the Hydra Study
Emily S.L. Martens, Bram Akerboom, Christine Baumgartner, Brouwer Re, Chiara Cavallaro, Michiel Coppens, +30 more
0citations -
Protocol, rationale and design of BE-PEOPLE (Bedaquiline enhanced exposure prophylaxis for LEprosy in the Comoros): a cluster randomized trial on effectiveness of rifampicin and bedaquiline as post-exposure prophylaxis of leprosy contacts
Younoussa Assoumani, Said Nourdine Samidine, Auke T. Bergeman, Alberto Piubello, Nissad Attoumani, Silahi Halifa Grillone, +14 more
22citations -
Robot-assisted versus open pancreatoduodenectomy for cancer in the pancreatic head (DIPLOMA-2x2): study protocol for an international multicentre patient- and assessor-blinded randomized controlled non-inferiority trial
Nine de Graaf, Caro L. Bruna, Julia E. Menso, Anouk M.L.H. Emmen, Bergþór Björnsson, Hakon Blomstrand, +54 more
1citations -
The ATLAS/NOA-29 study protocol: a phase III randomized controlled trial of anterior temporal lobectomy versus gross-total resection in newly-diagnosed temporal lobe glioblastoma
Matthias B. Schneider, Anna‐Laura Potthoff, Yahya Ahmadipour, Valeri Borger, Hans Clusmann, Stephanie Elisabeth Combs, +67 more
1citations -
Laparoscopic versus open parenchymal preserving liver resections in the posterosuperior segments (ORANGE Segments): a multicentre, single-blind, randomised controlled trial2025 The Lancet Regional Health - Europe article Medicine Hepatocellular Carcinoma Treatment and Prognosis Open access
Jasper P. Sijberden, Christoph Kuemmerli, Francesca Ratti, Mathieu D’Hondt, Robert Peter Sutcliffe, Roberto Ivan TROISI, +22 more
16citations -
Cost-effectiveness of treating advanced melanoma with tumor-infiltrating lymphocytes based on an international randomized phase 3 clinical trial2024 Journal for ImmunoTherapy of Cancer article Economics, Econometrics and Finance Health Systems, Economic Evaluations, Quality of Life Open access
Renske M.T. ten Ham, Maartje W. Rohaan, Inge Jedema, Rob Kessels, Wim Stegeman, Walter Scheepmaker, +10 more
15citations -
Trauma-focused treatments for refugee children: study protocol for a randomized controlled trial of the effectiveness of KIDNET versus EMDR therapy versus a waitlist control group (KIEM)
Merel E. Velu, Irene J. M. Martens, Mona K. Shahab, Carlijn de Roos, Ruud A. Jongedijk, Michaela Schok, +1 more
8citations -
Effectiveness and cost-effectiveness of MicroShunt implantation versus standard trabeculectomy for open-angle glaucoma (a SIGHT study): study protocol of a multicentre randomised controlled trial
Lotte M. J. Scheres, Frank J.H.M. van den Biggelaar, Björn Winkens, Stefani Kujovic‐Aleksov, Rogier P. H. M. Müskens, Peter W.T. de Waard, +8 more
8citations