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Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial2021 Annals of the Rheumatic Diseases article Medicine Rheumatoid Arthritis Research and Therapies Open access
René Westhovens, William F. C. Rigby, Désirée M F M van der Heijde, D. W. T. CHING, William Stohl, Jonathan Kay, +13 more
150citations -
Predictors of achieving clinical remission in ACPA-positive RA-patients treated with abatacept and methotrexate and methotrexate monotherapy: a post-hoc analysis of the AVERT and AVERT-II trials2026 Seminars in Arthritis and Rheumatism article Medicine Rheumatoid Arthritis Research and Therapies Open access
Sytske Anne Bergstra, M. Verstappen, E. Niemantsverdriet, Tom W. J. Huizinga, Annette H M van der Helm–van Mil
0citations -
Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities2020 Frontiers in Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Evelien G. E. Hurkmans, Marije J. Klumpers, Sita H. H. M. Vermeulen, Melanie M. Hagleitner, Uta E. Flucke, Hendrik W. B. Schreuder, +5 more
14citations -
An international, multicentre, interventional, randomised, assessor-blinded trial to MAXimise the METHotrexate therapy potential in patients with active rheumatoid arthritis (MethMax trial): study protocol for a randomised controlled trial
Karolina Anderle, Daniela Sieghart, Martina Durechova, François Bonnay, Andreas Kerschbaumer, Katerina Chatzidionysiou, +13 more
0citations -
Sustained Remission and Outcomes with Abatacept plus Methotrexate Following Stepwise Dose De-escalation in Patients with Early Rheumatoid Arthritis2023 Rheumatology and Therapy article Medicine Rheumatoid Arthritis Research and Therapies Open access
Paul E. Emery, Yoshiya Tanaka, Vivian P. Bykerk, Gustavo Citera, Clifton O. Bingham, Subhashis Banerjee, +8 more
16citations -
First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate2025 New England Journal of Medicine article Medicine Sarcoidosis and Beryllium Toxicity Research Open access
Vivienne Kahlmann, Montse Janssen Bonás, Catharina C. Moor, Jan C. Grutters, Rémy L.M. Mostard, H.N.A.J. van Rijswijk, +15 more
74citations -
The chemotherapeutic drug methotrexate selects for antibiotic resistance2021 EBioMedicine article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Jónína S. Guðmundsdóttir, Elizabeth G. Aarag Fredheim, Catharina I. M. Koumans, Joachim Hegstad, Po-Cheng Tang, Dan I. Andersson, +2 more
28citations -
Methotrexate plus or minus cetuximab as first‐line treatment in a recurrent or metastatic (R/M) squamous cell carcinoma population of the head and neck (SCCHN), unfit for cisplatin combination treatment, a phase Ib‐randomized phase II study Commence
Janneke C. Ham, Esther van Meerten, W. Edward Fiets, Laurens Victor Beerepoot, Frank J. F. Jeurissen, Marije Slingerland, +4 more
19citations -
The chemotherapeutic drug methotrexate selects for antibiotic resistance2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Jónína S. Guðmundsdóttir, Elizabeth G. Aarag Fredheim, Catharina I. M. Koumans, Joachim Hegstad, Po-Cheng Tang, Dan I. Andersson, +2 more
0citations -
Quantifying the Effect of Methotrexate on Adalimumab Response in Psoriasis by Pharmacokinetic–Pharmacodynamic Modeling2023 Journal of Investigative Dermatology article Immunology and Microbiology Psoriasis: Treatment and Pathogenesis Open access
Astrid M. van Huizen, Paul C. D. Bank, Gayle E. van der Kraaij, Annelie H. Musters, Celine I. Busard, Stef P. Menting, +9 more
7citations -
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Folate and B Vitamins Research Open access
Felix van der Krift, Dick W. Zijlmans, Rhythm Shukla, Ali Javed, Panagiotis I. Koukos, Laura L.E. Schwarz, +13 more
2citations -
OP0324 LONG-TERM SUSTAINABILITY OF METHOTREXATE INTERVENTION IN ANTICITRULLINATED PROTEIN ANTIBODY-POSITIVE AND AUTOANTIBODY-NEGATIVE ARTHRALGIA PATIENTS AT INCREASED RISK FOR RHEUMATOID ARTHRITIS ON DISEASE DEVELOPMENT AND DISEASE BURDEN; 5 YEAR RESULTS FROM THE TREAT EARLIER TRIAL2025 Annals of the Rheumatic Diseases conference-abstract Medicine Rheumatoid Arthritis Research and Therapies Open access
Quirine A Dumoulin, Hanna W. van Steenbergen, Doortje I Krijbolder, W. Edward Visser, S. Böhringer, Annette H M van der Helm–van Mil
4citations -
A Systematic Review Comparing Experimental Design of Animal and Human Methotrexate Efficacy Studies for Rheumatoid Arthritis: Lessons for the Translational Value of Animal Studies
Cathalijn H. C. Leenaars, Frans R. Stafleu, Maikel van Berlo, Tijmen Geurts, Tineke Coenen-de Roo, Jan‐Bas Prins, +6 more
22citations -
Methotrexate prolongs TNF inhibitor survival, but only in autoantibody-positive rheumatoid arthritis: a validation study2021 Annals of the Rheumatic Diseases article Medicine Rheumatoid Arthritis Research and Therapies Open access
Elise van Mulligen, Annette H M van der Helm–van Mil, Pascal H P de Jong
5citations -
POS0582 RISK-STRATIFIED COST-UTILITY ANALYSIS OF THE TREAT EARLIER TRIAL: ONE-YEAR METHOTREXATE TREATMENT FOR CLINICALLY SUSPECT ARTHRALGIA IS COST-EFFECTIVE IN ACPA NEGATIVE BUT NOT IN ACPA POSITIVE PATIENTS WITH AN INCREASED RISK FOR RA2025 Annals of the Rheumatic Diseases conference-abstract Economics, Econometrics and Finance Health Systems, Economic Evaluations, Quality of Life Open access
Elise van Mulligen, Quirine A Dumoulin, Maureen Rutten‐van Mölken, Annette H M van der Helm–van Mil
0citations -
Filgotinib versus placebo or adalimumab in patients with rheumatoid arthritis and inadequate response to methotrexate: a phase III randomised clinical trial2021 Annals of the Rheumatic Diseases article Medicine Rheumatoid Arthritis Research and Therapies Open access
Bernard G Combe, Alan Kivitz, Yoshiya Tanaka, Désirée M F M van der Heijde, Jesus Abraham Simón Campos, Herbert S. B. Baraf, +14 more
248citations -
Survival, neurocognitive function, and health-related quality of life outcomes after rituximab—methotrexate, BCNU, teniposide, and prednisolone for primary CNS lymphoma: Final results of the HOVON 105/ALLG NHL 24 study
Jacoline E. C. Bromberg, Samar Issa, Bronno van der Holt, Matthijs van der Meulen, Linda Dirven, Monique C. Minnema, +14 more
25citations -
Clinical characteristics and survival outcomes of patients with primary central nervous system lymphoma treated with high-dose methotrexate-based polychemotherapy and consolidation therapies
Fleur A. de Groot, Tim J. A. Dekker, Jeanette K. Doorduijn, Stefan Böhringer, Mirian Brink, Ruben A. L. de Groen, +35 more
13citations