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Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators2024 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, +10 more
11citations -
Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens2025 Annals of the Rheumatic Diseases article Immunology and Microbiology Complement system in diseases Open access
Haiyu Wang, Rick J. Groenland, Stef van der Meulen, Hanneke Kapsenberg, Christoph Gstöttner, Elena Domínguez‐Vega, +5 more
10citations -
Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury2022 Neurotherapeutics article Medicine Traumatic Brain Injury and Neurovascular Disturbances Open access
Inge A. M. van Erp, Iliana Michailidou, Thomas Arjan van Essen, Mathieu van der Jagt, Wouter A. Moojen, Wilco C. Peul, +2 more
67citations -
#3018 Iptacopan's rapid and sustained inhibition of overactive complement alternative pathway in C3G: Exploratory analysis from the Phase 3 APPEAR-C3G study2025 Nephrology Dialysis Transplantation article Immunology and Microbiology Complement system in diseases Open access
Erica Daina, Giuseppe Remuzzi, David Kavanagh, Imelda Schuhmann, Rubeen Israni, Hari Varun Kalluri, +4 more
0citations -
Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids2023 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access
Lonneke H. Gaykema, Rianne Y. van Nieuwland, Mette C. Dekkers, Mieke F. van Essen, Sebastiaan Heidt, Arnaud Zaldumbide, +3 more
17citations -
Expert guidance on when to screen, monitor, and initiate complement inhibition therapy in patients without classical PNH2026 Blood Red Cells & Iron article Immunology and Microbiology Complement system in diseases Open access
Vinod A. Pullarkat, Daria V. Babushok, Carlos M. de Castro, David Dingli, Jamie Lynn Koprivnikar, Jaroslaw Pawel Maciejewski, +8 more
0citations -
Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP2025 Molecular & Cellular Proteomics article Immunology and Microbiology Complement system in diseases Open access
Tereza Kadavá, Jürgen Strasser, Maryam Marefat, Victor C. Yin, Johannes Preiner, Leendert Adrianus Trouw, +1 more
5citations -
Inhibition of complement factor C5a or C5aR for cholesterol crystal embolism–related vascular thrombosis with microvascular injury and its consequences2024 Kidney International article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Chao Han, Elmina Mammadova‐Bach, Kanako Watanabe‐Kusunoki, Tâmisa Seeko Bandeira Honda, Yihong Li, Chenyu Li, +16 more
13citations -
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP222023 Current Research in Neurobiology article Neuroscience Hereditary Neurological Disorders Open access
Iliana Michailidou, Jeroen P. Vreijling, Matthijs Rumpf, Maarten Loos, Bastijn Koopmans, Nina Vlek, +6 more
8citations -
Combined inhibition of the complement component C5 and the TLR-coreceptor CD14 alters the posttraumatic response in fracture hematoma in a porcine polytrauma model2025 Innovative Surgical Sciences article Immunology and Microbiology Immune Response and Inflammation Open access
Klemens Horst, Ümit Mert, Johannes Greven, Felix Bläsius, Tom Eirik Mollnes, Markus Stefan Huber-Lang, +3 more
0citations -
Complement activation in secondary thrombotic microangiopathies2025 Nephrology Dialysis Transplantation article Immunology and Microbiology Complement system in diseases Open access
Johann Morelle, Fernando Caravaca‐Fontán, Fádi Fakhouri, Eleni A. Frangou, Annette N. Bruchfeld, Jürgen Floege, +9 more
18citations -
The role of complement activation in autoimmune liver disease2020 Autoimmunity Reviews article Medicine Liver Diseases and Immunity Open access cited by 1 patent
Maaike Biewenga, Arantza Fariña Sarasqueta, Maarten E. Tushuizen, Eveline S. M. de Jonge‐Muller, Bart van Hoek, Leendert Adrianus Trouw
35citations -
Combined C5 and CD14 inhibition balances immunological miRNA responses after multiple trauma in pigs2025 DataverseNL dataset Immunology and Microbiology Inflammation biomarkers and pathways Open access
Rald Groven, Ümit Mert, Johannes Greven, Zhizhen He, Nan Zhou, Martijn Poeze, +5 more
0citations -
Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys2022 Frontiers in Immunology article Medicine Organ Transplantation Techniques and Outcomes Open access
Neeltina M. Jager, Leonie H. Venema, Asel S. Arykbaeva, Anita H. Meter-Arkema, Petra J. Ottens, Cees van Kooten, +4 more
23citations -
Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice2022 International Journal of Molecular Sciences article Medicine Liver Disease Diagnosis and Treatment Open access
Florine Seidel, Robert Kleemann, Wim van Duyvenvoorde, Nikki van Trigt, Nanda Keijzer, Sandra van der Kooij, +10 more
15citations -
S183: PHASE III RANDOMIZED, MULTICENTER, OPEN-LABEL COMMODORE 1 TRIAL: COMPARISON OF CROVALIMAB VS ECULIZUMAB IN COMPLEMENT INHIBITOR-EXPERIENCED PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
Phillip Scheinberg, Diego V. Clé, Valentina Giai, Marek Hus, Jin Seok Kim, Cristina Barrenetxea Lekue, +11 more
5citations -
Switching between complement inhibitors in patients with PNH: A real-world analysis of strategy, efficacy, and safety.2025 Blood conference-abstract Immunology and Microbiology Complement system in diseases Open access
Morag Griffin, Bruno Fattizzo, Jong Wook Lee, Richard J. Kelly, Roochi Trikha, Yasutaka Ueda, +10 more
0citations -
Phase 3 randomized COMMODORE 1 trial: Crovalimab versus eculizumab in complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria2024 American Journal of Hematology article Immunology and Microbiology Complement system in diseases Open access
Phillip Scheinberg, Diego V. Clé, Jin Seok Kim, Erfan Nur, Mustafa Nuri Yenerel, Wilma Barcellini, +15 more
52citations