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Evaluation of Antiviral Drugs’ Central Nervous System Distribution Using In Vitro Blood–Brain and Blood-CSF Barrier Models: The Impact of Serum Protein Concentration2026 Cellular and Molecular Neurobiology article Neuroscience Barrier Structure and Function Studies Open access
Malik Johid Reza, Ukamaka O. Modebelu, Courtney Vail Fletcher, Nagadenahalli Byrareddy Siddappa, Robbyn Kimberly Anand, Tianyi Zhang, +6 more
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Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy2026 Clinical Pharmacology & Therapeutics article Neuroscience Transcranial Magnetic Stimulation Studies Open access
Catherine M.K.E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert Jan Doll, Maria Joanna Juachon, Michel J. A. M. van Putten, +2 more
1citations -
Do Brain Extracellular Fluid Concentrations Predict PET ‐Inferred Receptor Occupancy in Human CNS ? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands2026 Clinical Pharmacology & Therapeutics article Neuroscience Neurotransmitter Receptor Influence on Behavior Open access
Divakar Budda, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Barrier Structure and Function Studies Open access
Berfin Gülave, Divakar Budda, Mohammed A. A. Saleh, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
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Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration2022 Frontiers in Pharmacology article Neuroscience Barrier Structure and Function Studies Open access
Arthur J. Van De Vyver, Antje‐Christine Walz, Mariette Heins, Afsaneh Abdolzade‐Bavil, Thomas E. Kraft, Inja Waldhauer, +1 more
19citations -
Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations2021 Journal of Pharmacokinetics and Pharmacodynamics article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Chi Fong Loo, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
43citations -
Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
0citations -
Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo‐Controlled, Parallel Group, First‐In‐Human Study in Healthy Male Participants
Marella C. E. van Ruissen, Sebastiaan J. W. van Kraaij, Jana Wolfova, Yanick Botilde, Lutz Wollin, Naomi B. Klarenbeek
4citations -
Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Neuroscience and Neuropharmacology Research Open access
Aaron L. Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J. Knox, Anand K. Muthusamy, Jonathan S. Marvin, +9 more
2citations -
“Differential Cortical Effects of Synaptic versus Extrasynaptic GABAA Receptor Modulation with Lorazepam and Brexanolone: A Randomized, Double-Blind, Placebo-Controlled, Cross-over TMS and EEG Trial.”
Catherine M.K.E. de Cuba, Annika A. de Goede, Naser Hakimi, Linda Aulin, Aaron C. Koralek, Andrew Heitman, +7 more
0citations