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Papers matching “clinical samples” 52

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Procedure for pooling clinical outcome data from DRUP-like clinical trials using the OMOP model.
2025 Journal of Clinical Oncology conference-abstract Mathematics Statistical Methods in Clinical Trials

T.M. Kringelbach, Gro Live Fagereng, Gabriel Bratseth Stav, Maria Martin Agudo, Soemeya F. Haj Mohammad, Florentine A.J. Verbeek, +13 more

0

citations
Methodological insights from the EPISTOP trial to designing clinical trials in rare diseases—A secondary analysis of a randomized clinical trial
2024 PLoS ONE article Mathematics Statistical Methods in Clinical Trials Open access

Stephanie Wied, R.-D Hilgers, Nicole Maria Heussen, Katarzyna Kotulska, Maya Dirani, Mathieu Kuchenbuch, +2 more

2

citations
Clinical prediction models in psychiatry: a systematic review of two decades of progress and challenges
2022 Molecular Psychiatry review Mathematics Statistical Methods in Epidemiology Open access

Alan J. Meehan, Stephanie J. Lewis, Seena Fazel, Paolo Fusar‐Poli, Ewout Willem Steyerberg, Daniel R. Stahl, +1 more

213

citations
Multi-stakeholder sessions on major innovation topics in rare disease clinical trials
2024 Orphanet Journal of Rare Diseases article Mathematics Statistical Methods in Clinical Trials Open access

Daniel Bodden, Stefanie Schoenen, Stephanie Wied, Johan Verbeeck, Maya Dirani, Nicole Maria Heussen, +3 more

3

citations
Generalizability of Cardiovascular Disease Clinical Prediction Models: 158 Independent External Validations of 104 Unique Models
2022 Circulation Cardiovascular Quality and Outcomes article Mathematics Statistical Methods in Epidemiology Open access

David V. Klaveren

54

citations
The difference between statistical significance and clinical relevance. The case of minimal important change, non-inferiority trials, and smallest worthwhile effect
2023 Injury article Mathematics Statistical Methods in Clinical Trials Open access

Nienke Willemien Willigenburg, Rudolf Wilhelm Poolman

42

citations
Blueprint for mechanistic, data‐rich early phase clinical pharmacology studies in dermatology
2020 British Journal of Clinical Pharmacology article Mathematics Statistical Methods in Clinical Trials Open access

Robert Rißmann, Matthijs Moerland, Martijn B. A. van Doorn

13

citations
An Empirical Assessment of the Cost of Dichotomization of the Outcome of Clinical Trials
2026 Statistics in Medicine article Mathematics Statistical Methods in Clinical Trials Open access

Erik W. van Zwet, Frank E. Harrell, Stephen John Senn

7

citations
Adaptive sample size determination for the development of clinical prediction models
2021 Diagnostic and Prognostic Research article Mathematics Statistical Methods in Epidemiology Open access

Evangelia Christodoulou, Maarten van Smeden, Michael Edlinger, Dirk Timmerman, Maria M. Wanitschek, Ewout Willem Steyerberg, +1 more

38

citations
Adaptive sample size determination for the development of clinical prediction models
2020 Research Square preprint Mathematics Statistical Methods in Epidemiology Open access

Evangelia Christodoulou, Maarten van Smeden, Michael Edlinger, Dirk Timmerman, Maria M. Wanitschek, Ewout Willem Steyerberg, +1 more

1

citations
How to develop, validate, and update clinical prediction models using multinomial logistic regression
2024 Journal of Clinical Epidemiology article Mathematics Statistical Methods in Epidemiology Open access

Celina K Gehringer, Glen Philip Martin, Ben Van Calster, Kimme Leanne Hyrich, Suzanne M. M. Verstappen, Jamie C. Sergeant

20

citations
A comparison of hyperparameter tuning procedures for clinical prediction models: A simulation study
2024 Statistics in Medicine article Mathematics Statistical Methods and Inference Open access

Zoë S Dunias, Ben Van Calster, Dirk Timmerman, Anne‐Laure Boulesteix, Maarten van Smeden

35

citations
The Generalizability of Clinical Prediction Models for Patients with Acute Coronary Syndromes: Results from Independent External Validations
2021 medRxiv preprint Mathematics Statistical Methods in Epidemiology Open access

Benjamin S. Wessler, Jason Nelson, Jinny G. Park, Hannah L. McGinnes, Jenica N. Upshaw, Ben Van Calster, +3 more

0

citations
Randomization in clinical trials with small sample sizes using group sequential designs
2025 PLoS ONE article Mathematics Statistical Methods in Clinical Trials Open access

Daniel Bodden, R.-D Hilgers, Franz König

3

citations
Calculating the sample size required for developing a clinical prediction model
2020 BMJ article Mathematics Statistical Methods in Epidemiology Open access

Richard D Riley, Joie Ensor, Kym I E Snell, Frank E. Harrell, Glen Philip Martin, Johannes B. Reitsma, +3 more

2,902

citations
The impact of allocation bias on test decisions in clinical trials with multiple endpoints using multiple testing strategies
2024 BMC Medical Research Methodology article Mathematics Statistical Methods in Clinical Trials Open access

Stefanie Schoenen, Nicole Maria Heussen, Johan Verbeeck, R.-D Hilgers

6

citations
Comparison of likelihood penalization and variance decomposition approaches for clinical prediction models: A simulation study
2023 Biometrical Journal article Mathematics Statistical Methods and Inference Open access

Rolf H. H. Groenwold, Maarten van Smeden

3

citations
A roadmap to using randomization in clinical trials
2021 BMC Medical Research Methodology article Mathematics Statistical Methods in Clinical Trials Open access

Vance W. Berger, Louis Bour, Kerstine Carter, Jonathan Chipman, Colin Charles Everett, Nicole Maria Heussen, +7 more

138

citations
A roadmap to using randomization in clinical trials
2021 Research Square preprint Mathematics Statistical Methods in Clinical Trials Open access

Vance W. Berger, Louis Bour, Kerstine Carter, Jonathan Chipman, Colin Charles Everett, Nicole Maria Heussen, +7 more

1

citations
Future of clinical trials in the delivery room: time for pragmatism
2022 Archives of Disease in Childhood Fetal & Neonatal article Mathematics Statistical Methods in Clinical Trials Open access

Colm Patrick Finbarr O’Donnell, Janneke Dekker, Mario Rüdiger, Arjan B. te Pas

5

citations
Evaluation of the Fill-it-up-design to use historical control data in randomized clinical trials with two arm parallel group design
2024 BMC Medical Research Methodology article Mathematics Statistical Methods in Clinical Trials Open access

Stephanie Wied, Martin Posch, Ralf-Dieter Hilgers

3

citations
Moving the Needle for Oncology Dose Optimization: A Call for Action
2024 Clinical Pharmacology & Therapeutics article Mathematics Statistical Methods in Clinical Trials

Karthik Venkatakrishnan, Priya Jayachandran, Shirley K. Seo, Piet H. van der Graaf, John A. Wagner, Neeraj Gupta

5

citations
The role of research ethics committees in addressing optimism in sample size calculations: a meta-epidemiological study
2025 Figshare other Mathematics Statistical Methods in Clinical Trials Open access

Olaf M. Dekkers

0

citations
The role of research ethics committees in addressing optimism in sample size calculations: a meta-epidemiological study
2025 Research Integrity and Peer Review article Mathematics Statistical Methods in Clinical Trials Open access

Marieke S. Jansen, Rolf H. H. Groenwold, Olaf M. Dekkers

0

citations
The role of research ethics committees in addressing optimism in sample size calculations: a meta-epidemiological study
2025 Figshare other Mathematics Statistical Methods in Clinical Trials Open access

Rolf H. H. Groenwold, Olaf M. Dekkers

0

citations