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Critical appraisal of combination therapies: the impact of trial design on benefit-risk outcomes2026 JNCI Journal of the National Cancer Institute article Mathematics Statistical Methods in Clinical Trials
Floor de Jong, Li-Anne H Douma, Paul Baas, Cornedine Jannette de Gooijer, Hans A. J. Gelderblom, Jacobus A. Burgers, +1 more
0citations -
Decision curve analysis: confidence intervals and hypothesis testing for net benefit2023 Diagnostic and Prognostic Research article Mathematics Statistical Methods in Epidemiology Open access cited by 1 patent
Andrew Julian Vickers, Ben Van Claster, Laure Wynants, Ewout Willem Steyerberg
42citations -
A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases2020 arXiv (Cornell University) preprint Mathematics Advanced Causal Inference Techniques Open access
Alexandros Rekkas, David V. Klaveren, Patrick B. Ryan, Ewout Willem Steyerberg, David M. Kent, Peter R. Rijnbeek
1citations -
Regulatory Issues of Platform Trials: Learnings from EU‐PEARL2024 Clinical Pharmacology & Therapeutics article Mathematics Statistical Methods in Clinical Trials Open access
Katharina Hees, Sabina Hernandez Penna, Franz König, Martin Posch, Marta Bofill Roig, Elias Laurin Meyer, +11 more
17citations -
Methodological guidance for the evaluation and updating of clinical prediction models: a systematic review2022 BMC Medical Research Methodology review Mathematics Statistical Methods in Epidemiology Open access
Mary Ann E. Binuya, Ellen G. Engelhardt, Winnie Schats, Marjanka K. Schmidt, Ewout Willem Steyerberg
233citations -
Assessing Performance and Clinical Usefulness in Prediction Models With Survival Outcomes: Practical Guidance for Cox Proportional Hazards Models2022 Annals of Internal Medicine article Mathematics Statistical Methods in Epidemiology Open access
David J. McLernon, Daniele Giardiello, Ben Van Calster, Laure Wynants, Nan van Geloven, Maarten van Smeden, +18 more
164citations -
Maximizing Treatment Opportunities: Assessing Protocol Waivers’ Impact on Safety and Outcome in the Drug Rediscovery Protocol2024 Clinical Cancer Research article Mathematics Statistical Methods in Clinical Trials Open access
Jade M. van Berge Henegouwen, Laurien Joanna Zeverijn, Birgit S. Geurts, Louisa Rose Hoes, Hanneke van der Wijngaart, Vincent van der Noort, +7 more
2citations -
Population-Level Decision Curve Analysis May Mislead the Evaluation of Prediction Model Usefulness under Subgroup Utility Heterogeneity2026 arXiv (Cornell University) preprint Mathematics Statistical Methods in Epidemiology Open access
Junfeng Wang, Kim Zhipei Wang, Ben Van Calster, Nan van Geloven, Ewout Willem Steyerberg, Laure Wynants
0citations -
Procedure for pooling clinical outcome data from DRUP-like clinical trials using the OMOP model.2025 Journal of Clinical Oncology conference-abstract Mathematics Statistical Methods in Clinical Trials
T.M. Kringelbach, Gro Live Fagereng, Gabriel Bratseth Stav, Maria Martin Agudo, Soemeya F. Haj Mohammad, Florentine A.J. Verbeek, +13 more
0citations -
Measuring the success of blinding in placebo-controlled trials: Should we be so quick to dismiss it?2021 Journal of Clinical Epidemiology article Mathematics Statistical Methods in Clinical Trials Open access
Rebecca Webster, Felicity L. Bishop, Professor Gary S. Collins, Andrea W.M. Evers, Tammy Hoffmann, J. André Knottnerus, +7 more
26citations -
Healthy volunteers in first‐in‐human oncology drug development for small molecules2021 British Journal of Clinical Pharmacology article Mathematics Statistical Methods in Clinical Trials Open access
Begoña de las Heras, Dalila Bouyoucef‐Cherchalli, Lesley Reeve, Andreas Reichl, Debra Mandarino, Stephen D. Flach, +3 more
18citations -
Predictive approaches to heterogeneous treatment effects: a scoping review2020 BMC Medical Research Methodology article Mathematics Statistical Methods in Clinical Trials Open access
Alexandros Rekkas, Jessica K. Paulus, Gowri Raman, John B. Wong, Ewout Willem Steyerberg, Peter R. Rijnbeek, +2 more
88citations -
Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study2021 Journal of Neurotrauma article Mathematics Statistical Methods and Bayesian Inference Open access
Benjamin Yaël Gravesteijn, Charlie Aletta Sewalt, Esmée Venema, Daan Nieboer, Ewout Willem Steyerberg, Cecilia A. I. Åkerlund, +92 more
44citations -
Histology independent drug development – Is this the future for cancer drugs?2023 Cancer Treatment Reviews article Mathematics Statistical Methods in Clinical Trials Open access
Lucinda Jane Billingham, Theodor Framke, Alastair Greystoke, Eivind J. Hovig, Philippe Page, Elias Péan, +4 more
6citations
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