-
bletl ‐ A Python package for integrating BioLector microcultivation devices in the Design‐Build‐Test‐Learn cycle2022 Engineering in Life Sciences software-paper Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Michael Osthege, Niklas Tenhaef, Rebecca Zyla, Carolin Müller, Johannes Hemmerich, Wolfgang Wiechert, +2 more
42citations -
One‐shot 13C15N‐metabolic flux analysis for simultaneous quantification of carbon and nitrogen flux2023 Molecular Systems Biology article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Khushboo Borah, Martin Beyß, Ye Xu, Jim Barber, Catia Costa, Jane Newcombe, +5 more
38citations -
Bayesian calibration, process modeling and uncertainty quantification in biotechnology2022 PLoS Computational Biology article Decision Sciences Optimal Experimental Design Methods Open access cited by 1 patent
Laura M. Helleckes, Michael Osthege, Wolfgang Wiechert, Eric von Lieres, Marco Oldiges
34citations -
High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 130322021 Frontiers in Microbiology article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access cited by 1 patent
Martina Feierabend, Alina Renz, Elisabeth Zelle, Katharina Nöh, Wolfgang Wiechert, Andreas Dräger
33citations -
Screening of a genome‐reduced Corynebacterium glutamicum strain library for improved heterologous cutinase secretion2020 Microbial Biotechnology article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Johannes Hemmerich, Carmen Steffens, Sebastian J. Reich, Marc Weiske, Meike Baumgart, Christian Rückert, +6 more
29citations -
Construction and comprehensive characterization of an EcLDCc-CatIB set—varying linkers and aggregation inducing tags2021 Microbial Cell Factories article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access cited by 1 patent
Kira Küsters, Martina Pohl, Ulrich Krauß, Gizem Ölçücü, Karl‐Erich Jaeger, Wolfgang Wiechert, +1 more
24citations -
Explore or exploit? A model‐based screening strategy for PETase secretion by Corynebacterium glutamicum2022 Biotechnology and Bioengineering article Biochemistry, Genetics and Molecular Biology Enzyme Production and Characterization Open access
Laura M. Helleckes, Carolin Müller, Tim Griesbach, Vera Waffenschmidt, Matthias Moch, Michael Osthege, +2 more
22citations -
Microaerobic growth‐decoupled production of α‐ketoglutarate and succinate from xylose in a one‐pot process using Corynebacterium glutamicum2021 Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Niklas Tenhaef, Jannick Kappelmann, Arabel Eich, Marc Weiske, Lisette Brieß, Christian Brüsseler, +3 more
22citations -
Communities of Niche-optimized Strains (CoNoS) – Design and creation of stable, genome-reduced co-cultures2022 Metabolic Engineering article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Simone Schito, Rico Zuchowski, Daniel Bergen, Daniel Strohmeier, Bastian Wollenhaupt, Philipp Menke, +7 more
19citations -
High-throughput screening of catalytically active inclusion bodies using laboratory automation and Bayesian optimization2024 Microbial Cell Factories article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
Laura M. Helleckes, Kira Küsters, Rebecca Hamel, Ronja Saborowski, Jan Marienhagen, Wolfgang Wiechert, +1 more
16citations -
Enabling oxygen-controlled microfluidic cultures for spatiotemporal microbial single-cell analysis2023 Frontiers in Microbiology article Engineering Microfluidic and Capillary Electrophoresis Applications Open access
Keitaro Kasahara, Markus Leygeber, Johannes Seiffarth, Karina Ruzaeva, Thomas Drepper, Katharina Nöh, +1 more
16citations -
A Guide to Bayesian Optimization in Bioprocess Engineering2026 Biotechnology and Bioengineering article Decision Sciences Optimal Experimental Design Methods Open access
Maximilian Siska, Emma Pajak, Katrin Rosenthal, Ehecatl Antonio del Rio‐Chanona, Eric von Lieres, Laura M. Helleckes
15citations -
Accelerated strain construction and characterization of C. glutamicum protein secretion by laboratory automation2022 Applied Microbiology and Biotechnology article Biochemistry, Genetics and Molecular Biology Bacterial Genetics and Biotechnology Open access cited by 1 patent
Carolin Müller, Patrick J. Bakkes, Vera Waffenschmidt, Laura M. Helleckes, Karl‐Erich Jaeger, Wolfgang Wiechert, +3 more
14citations -
Scaling production of GFP1-10 detector protein in E. coli for secretion screening by split GFP assay2021 Microbial Cell Factories article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Carolin Müller, Chika Linda Igwe, Wolfgang Wiechert, Marco Oldiges
12citations -
Control of parallelized bioreactors II: probabilistic quantification of carboxylic acid reductase activity for bioprocess optimization2022 Bioprocess and Biosystems Engineering article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Nikolas von den Eichen, Michael Osthege, Lukas Bromig, Wolfgang Wiechert, Marco Oldiges, Dirk Weuster‐Botz
11citations -
Need for speed: evaluation of dilute and shoot-mass spectrometry for accelerated metabolic phenotyping in bioprocess development2021 Analytical and Bioanalytical Chemistry article Biochemistry, Genetics and Molecular Biology Metabolomics and Mass Spectrometry Studies Open access
Alexander M. Reiter, Laura Herbst, Wolfgang Wiechert, Marco Oldiges
11citations -
Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis2021 Frontiers in Bioengineering and Biotechnology article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Martin Beyß, Victor D. Parra-Peña, Howard Ramírez-Malule, Katharina Nöh
10citations -
From frozen cell bank to product assay: high-throughput strain characterisation for autonomous Design-Build-Test-Learn cycles2023 Microbial Cell Factories article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Laura M. Helleckes, Debora Puchta, Hannah Czech, Holger Morschett, Bertram Geinitz, Wolfgang Wiechert, +1 more
9citations