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January 01, 2026 article Open access

Plasma Concentration Is Not Enough for Phytochemical Lead Selection When Tissue Distribution, Unbound Exposure, and Site-of-Action Pharmacokinetics Determine Efficacy

International Journal of Pharmaceutical and Phytopharmacological Research

DOI: 10.51847/faevs6tvkf Full text (OA) OpenAlex

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Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
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2022 Clinical Pharmacokinetics article Medicine Antibiotics Pharmacokinetics and Efficacy Open access

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Spatial Pharmacokinetic and Pharmacodynamic Modeling in Airway Mucus
2025 Clinical Pharmacokinetics article Medicine Antibiotics Pharmacokinetics and Efficacy Open access

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Changes in Plasma Clearance of CYP450 Probe Drugs May Not be Specific for Altered In Vivo Enzyme Activity Under (Patho)Physiological Conditions: How to Interpret Findings of Probe Cocktail Studies
2024 Clinical Pharmacokinetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

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