689P Predicting oncotype DX recurrence score using clinicopathological variables in HR-positive, HER2-negative breast cancer: A real-world analysis from an Italian breast unit

ESMO Open, vol. 11, pp. 107377

Abstract

Adjuvant therapy decisions in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) can be guided by the Oncotype DX (ODX) Recurrence Score (RS). High costs and centralized testing limit applicability. We aimed to develop a predictive model used to identify patients with high-risk RS (≥26) and assess associations between clinicopathological variables and high-risk RS.

Authors 11

1. P.J. Paganoni Aachen Student

   Leiden University Medical Center

   Affiliation as printed

   Student, LUMC - Leiden University Medical Center, Leiden, Netherlands

2. M. Laganà

   Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

   Affiliation as printed

   Department of Oncology, ASST Spedali Civili di Brescia, Brescia, Italy

3. Matteo Rota

   University of Brescia

   Affiliation as printed

   Molecular and Translational Medicine, University of Brescia, Brescia, Italy

4. D. Cosentini

   Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

   Affiliation as printed

   Dipartimento di Oncologia Medica, Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy

5. G. Mola

   Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

   Affiliation as printed

   Oncology department, ASST Spedali Civili di Brescia, Brescia, Italy

6. G. Schivardi

   Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

   Affiliation as printed

   Department of Medical Oncology, ASST Spedali Civili di Brescia, Brescia, Italy

7. A. Bianchi

   Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

   Affiliation as printed

   Breast Unit, Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy

8. S. Strazzeri

   University of Brescia

   Affiliation as printed

   Oncologia medica, UNIBS - Università degli Studi di Brescia - Facoltà di Medicina e Chirurgia, Brescia, Italy

9. A. Berruti

   Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

   Affiliation as printed

   Dipatimento di Oncologia Medica, ASST Spedali Civili di Brescia, Brescia, Italy

10. S. Grisanti

    Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

    Affiliation as printed

    Medical Oncology Dept., ASST Spedali Civili di Brescia, Brescia, Italy

11. R. Pedersini

    Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

    Affiliation as printed

    Oncologia dept., Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy