Single-molecule glycan discrimination using a graphite nanopore

Nanoscale, vol. 18, pp. 12920–12929

Abstract

-acetylation pattern, and regioisomeric structure are reliably discriminated. In fact, from a mechanistic perspective, distinct ionic current signatures are traced back to species-specific spatial charge accumulation around individual glycans confined within the nanopore lumen. Moreover, under applied transmembrane voltage, the negatively charged nanopore generates electroosmotic flow, which drives glycan translocation and offers a chemically label-free approach for glycan detection.

Authors 2

1. Chandan Kumar Das Aachen Center for Computational Life Sciences Computational Biotechnology

   RWTH Aachen University

   Affiliation as printed

   Center for Computational Life Sciences (CCLS), RWTH Aachen University, Pauwelsstrasse 19, 52072, Aachen, Germany

   Computational Biotechnology, RWTH Aachen University, Worrignerweg 3, 52074, Aachen, Germany

2. Maria Fyta Aachen Center for Computational Life Sciences Computational Biotechnology

   RWTH Aachen University

   Affiliation as printed

   Center for Computational Life Sciences (CCLS), RWTH Aachen University, Pauwelsstrasse 19, 52072, Aachen, Germany

   Computational Biotechnology, RWTH Aachen University, Worrignerweg 3, 52074, Aachen, Germany