Recommendations for HLA Genotyping Data Standards and Clinical Laboratory Staffing Considerations

HLA, vol. 107, pp. e70725

Abstract

The rapid advances in HLA genotyping technology and the massive amounts of associated data have created a demand for better and more efficient laboratory data management practices. However, while some standards have been developed, there is a need for comprehensive guidelines that include all laboratory data-related processes such as messaging, storage and retention, documentation, reporting, validation and quality control. An important consideration in developing these recommendations is the feasibility of application in a laboratory setting without posing a substantial staff and cost burden for implementation and long-term maintenance and the availability of publicly available tools. This article presents evidence-based recommendations for multiple laboratory general data practices, focusing on HLA genotyping data and associated meta-data. These recommendations are compiled by experts in the fields of histocompatibility and immunogenetics (H&I) and representation from multiple H&I worldwide professional society leadership with the long-term goal of adopting these recommendations in future laboratory accreditation requirements.

Authors 9

1. Eric Spierings corresponding

   University Medical Center Utrecht

   Affiliation as printed

   Laboratory for Translational Immunology and Central Diagnostics Laboratory, University Medical Center Utrecht the Netherlands

   Matchis Foundation Leiden the Netherlands

2. N M Brown

   University of Pennsylvania

   Affiliation as printed

   Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia Pennsylvania USA

3. Katy Latham
   Affiliation as printed

   Histocompatibility and Immunogenetics, NHS Blood & Transplant London UK

4. James Theodore Robinson

   Anthony Nolan · The Royal Free Hospital · University College London

   Affiliation as printed

   Anthony Nolan Research Institute London UK

   Royal Free Hospital, University College London Cancer Institute London UK

5. Medhat Z. Askar

   Qatar University

   Affiliation as printed

   Health Sector and College of Medicine, Qatar University Doha Qatar

6. Gerald P. Morris

   University of California San Diego

   Affiliation as printed

   Department of Pathology University of California San Diego California USA

7. Eric T. Weimer

   University of North Carolina at Chapel Hill

   Affiliation as printed

   Department of Pathology and Laboratory Medicine The University of North Carolina at Chapel Hill School of Medicine Chapel Hill North Carolina USA

8. Martin J. Maiers

   National Marrow Donor Program

   Affiliation as printed

   CIBMTR (Center for International Blood and Marrow Transplant Research), NMDP Minneapolis Minnesota USA

9. Abeer S. Madbouly
   Affiliation as printed

   MHC Therapeutics Bioconsulting Minneapolis Minnesota USA