Beta‐3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline‐Induced Pulmonary Hypertension Model

Pulmonary Circulation, vol. 16, pp. e70232

Abstract

Considering the beta-3 adrenoceptor agonist, mirabegron, may display vasodilator and cardioprotective properties, we investigated the therapeutic potential of mirabegron in monocrotaline-induced pulmonary hypertension in rats. High-dose mirabegron improved right ventricular function, and endothelium-dependent relaxation in isolated rat pulmonary arteries, suggesting that mirabegron may be beneficial in pulmonary arterial hypertension.

Authors 14

1. Pedro Mendes‐Ferreira

   Inserm · Universidade do Porto · Université Paris-Saclay · KU Leuven

   Affiliation as printed

   Laboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA) KU Leuven – University of Leuven Leuven Belgium

   Paris‐Porto Pulmonary Hypertension Collaborative Laboratory (3PH), UMR_S 999, INSERM Université Paris‐Saclay Le Kremlin‐Bicêtre France

   RISE‐Health, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal

2. Birger Tielemans Aachen Institute of Pathology

   Universitätsklinikum Aachen · RWTH Aachen University · KU Leuven

   Affiliation as printed

   Department of Imaging and Pathology KU Leuven – University of Leuven Leuven Belgium

   Institute of Pathology University Hospital RWTH Aachen Aachen Germany

   Laboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA) KU Leuven – University of Leuven Leuven Belgium

3. Allard Wagenaar

   KU Leuven

   Affiliation as printed

   Laboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA) KU Leuven – University of Leuven Leuven Belgium

4. C. Bouzin

   UCLouvain

   Affiliation as printed

   IREC Imaging Platform (2IP, RRID: SCR_023378), Institute of Experimental and Clinical Research (IREC) Université catholique de Louvain (UCLouvain) Brussels Belgium

5. Rui Adão

   Universidad Complutense de Madrid · Universidade do Porto · Centro de Investigación Biomédica en Red de Enfermedades Respiratorias · Centro de Investigación Biomédica en Red

   Affiliation as printed

   CIBER Enfermedades Respiratorias (Ciberes) Madrid Spain

   Department of Pharmacology and Toxicology, School of Medicine University Complutense of Madrid Madrid Spain

   RISE‐Health, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal

6. Péter Pokreisz

   Medical University of Vienna · KU Leuven

   Affiliation as printed

   Center for Biomedical Research and Translational Surgery Medical University of Vienna Vienna Austria

   Department of Cardiovascular Sciences KU Leuven – University of Leuven, Campus Gasthuisberg Leuven Belgium

7. Delphine De Mulder

   UCLouvain

   Affiliation as printed

   Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC) Université catholique de Louvain (UCLouvain) Brussels Belgium

8. Adelino Ferreira Leite-Moreira

   Universidade do Porto

   Affiliation as printed

   RISE‐Health, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal

9. Carmen Brás‐Silva

   Universidade do Porto

   Affiliation as printed

   RISE‐Health, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal

10. Jean‐Luc Balligand

    Cliniques Universitaires Saint-Luc · UCLouvain

    Affiliation as printed

    Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), and Cliniques Universitaires Saint‐Luc Université catholique de Louvain (UCLouvain) Brussels Belgium

11. C. Dessy

    UCLouvain

    Affiliation as printed

    Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC) Université catholique de Louvain (UCLouvain) Brussels Belgium

12. Marion Delcroix

    KU Leuven

    Affiliation as printed

    Laboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA), Clinical Department of Respiratory Diseases University Hospitals KU Leuven – University of Leuven Leuven Belgium

13. Rozenn Anne Quarck

    KU Leuven

    Affiliation as printed

    Laboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA), Clinical Department of Respiratory Diseases University Hospitals KU Leuven – University of Leuven Leuven Belgium

14. Catharina Belge corresponding

    KU Leuven

    Affiliation as printed

    Laboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA), Clinical Department of Respiratory Diseases University Hospitals KU Leuven – University of Leuven Leuven Belgium