W6644804947

• Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

  2025 GeroScience article Biochemistry, Genetics and Molecular Biology Genetics, Aging, and Longevity in Model Organisms Open access

  2

  citations
• Site-directed multivalent conjugation of antibodies to ubiquitinated payloads

  2025 Nature Biomedical Engineering article Medicine Monoclonal and Polyclonal Antibodies Research Open access

  10

  citations
• Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment

  2024 Current Cardiology Reports article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access

  6

  citations
• Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy

  2023 Nature article Medicine Autophagy in Disease and Therapy Open access

  91

  citations
• Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

  2023 Nature Biotechnology article Medicine Liver Disease Diagnosis and Treatment Open access cited by 1 patent

  248

  citations
• Ubi-tagging: A ubiquitin-based modular platform for site-directed antibody conjugation

  2022 Research Square preprint Medicine Monoclonal and Polyclonal Antibodies Research Open access

  5

  citations
• T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

  2021 Nature Biotechnology article Medicine CAR-T cell therapy research Open access cited by 7 patents

  36

  citations
• TGF-β-mediated Endothelial to Mesenchymal Transition (EndMT) and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing

  2021 Journal of Visualized Experiments article Biochemistry, Genetics and Molecular Biology TGF-β signaling in diseases Open access

  12

  citations
• Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver

  2020 Nature Protocols article Medicine Liver physiology and pathology Open access cited by 1 patent

  159

  citations
• The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s

  2020 Nature Communications article Immunology and Microbiology interferon and immune responses Open access

  180

  citations
• Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes

  2020 Scientific Reports article Medicine Chemotherapy-induced cardiotoxicity and mitigation Open access

  49

  citations
• Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing

  2020 Nature Cell Biology article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 15 patents

  300

  citations

12 results