Comparative cost analysis of a diagnostic multi-omics platform for decision support in advanced cancer – results from the Tumor Profiler Melanoma project

npj Precision Oncology, vol. 10, pp. 35

Abstract

While advances in the understanding of tumor biology through multi-omics profiling hold the promise of substantially improving patient outcomes, the cost implications of such strategies remain unclear. We therefore performed a comparative cost analysis of patients treated either within the Tumor Profiler (TuPro) melanoma project or from a control cohort who received treatment after standard next-generation sequencing testing. After adjustment of cohorts through inverse probability of treatment weighting, we found no evidence of statistically significant differences in total costs between the two cohorts (95% confidence interval -10% to +67%). Importantly, treatment costs (95% confidence interval -28% to +41%) were similar between the two cohorts. In conclusion, we found no evidence that treatment recommendations guided by advanced multi-omics profiling led to significantly higher treatment costs in a Swiss context.

Authors 11

1. Tarun Mehra

   University of Zurich · University Hospital Zurich

   Affiliation as printed

   Faculty of Medicine, University of Zurich, Zurich, Switzerland

   University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091, Zurich, Switzerland

2. Dominik Menges

   University of Zurich · Karolinska Institutet

   Affiliation as printed

   Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet (KI), Stockholm, Sweden

   Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH), Zurich, Switzerland

3. Benedict Gosztonyi

   University of Zurich · University Hospital Zurich

   Affiliation as printed

   Faculty of Medicine, University of Zurich, Zurich, Switzerland

   University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091, Zurich, Switzerland

4. Nicola Miglino

   University of Zurich · University Hospital Zurich

   Affiliation as printed

   Faculty of Medicine, University of Zurich, Zurich, Switzerland

   University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091, Zurich, Switzerland

5. Alexander Ring

   University of Zurich · University Hospital Zurich

   Affiliation as printed

   Faculty of Medicine, University of Zurich, Zurich, Switzerland

   University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091, Zurich, Switzerland

6. Laura Amanda Boos

   University of Zurich · University Hospital Zurich

   Affiliation as printed

   Faculty of Medicine, University of Zurich, Zurich, Switzerland

   University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091, Zurich, Switzerland

7. Bettina Sobottka

   University of Zurich · University Hospital Zurich

   Affiliation as printed

   Department of Pathology and Molecular Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland

8. Melike Ak

   University of Zurich · University Hospital Zurich

   Affiliation as printed

   University Hospital Zurich, Department of Dermatology, Gloriastrasse 31, 8091, Zurich, Switzerland

   Department of Pathology and Molecular Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland

   Faculty of Medicine, University of Zurich, Zurich, Switzerland

9. Bernd Bodenmiller

   University of Zurich · ETH Zurich · Institute of Molecular Health Sciences

   Affiliation as printed

   ETH Zurich, Institute of Molecular Health Sciences, Otto-Stern-Weg 7, 8093, Zurich, Switzerland

   University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057, Zurich, Switzerland

10. Viola A Heinzelmann-Schwarz

    University of Basel · University Hospital of Basel

    Affiliation as printed

    University Hospital Basel and University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031, Basel, Switzerland

    University Hospital Basel, Gynecological Cancer Center, Spitalstrasse 21, 4031, Basel, Switzerland

11. Francis Jacob

    University of Basel · University Hospital of Basel

    Affiliation as printed

    University Hospital Basel and University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031, Basel, Switzerland