Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy
Clinical Transplantation, vol. 39, pp. e70346
Abstract
BACKGROUND: Allogeneic hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) have evolved into successful, curative treatments for many severe congenital and acquired diseases. Both use medical products of human origin and should therefore have overarching regulatory frameworks. Both require critical decisions about donor selection, donor/recipient matching, immunosuppression, and long-term care, all tasks best performed by a trained, highly specialized multidisciplinary team. Both need committed institutions and governmental support for their success. Whereas the main barrier for performing SOT is the lack of suitable organs, access to a transplant center is the main limitation for HCT, which remains a highly specialized, complex, resource-intensive, and costly medical procedure. METHODS AND RESULTS: Here, we describe the main indications for HCT and SOT, their similarities and differences regarding donor selection, treatment prior to transplant, intensity and duration of immunosuppression after transplantation, their main complications, and consequences of donation for living donors. CONCLUSIONS: Strategies to improve worldwide access to HCT and SOT are discussed, as well as future developments in this highly innovative field of medicine.
Authors 14
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Affiliation as printed
University of Minnesota Medical School Minneapolis USA
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University of London · St George's Hospital · St George's, University of London
Affiliation as printed
Infection and Immunity Group, City St George's, Department of Haematology St George's University Hospitals, University of London London UK
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Lydia Foeken Aachen
World Marrow Donor Association
Affiliation as printed
WMDA (World Marrow Donor Association) Leiden the Netherlands
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Affiliation as printed
Department of Transfusion Medicine and Cell Therapy Medical University Vienna Vienna Austria
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Affiliation as printed
Divsion of Nephrology, Department of Medicine Nova Scotia Health; Kidney Research Institute Nova Scotia Nova Scotia Canada
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Baylor University Medical Center · Baylor Scott & White Health
Affiliation as printed
Kidney Transplant, Baylor Dallas Scott and White Health Dallas USA
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Affiliation as printed
Department of Medicine Weill Cornell Medical College New York USA
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Hospital Samaritano de São Paulo · Universidade Federal de São Paulo
Affiliation as printed
Hospital Samaritano & Pediatric Oncology Institute ‐ Graacc – Unifesp Sao Paulo Brazil
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Affiliation as printed
Department of Pulmonary Medicine Cleveland Clinic Cleveland Ohio USA
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Aichi Medical University · The Japanese Data Center for Hematopoietic Cell Transplantation
Affiliation as printed
Department of Registry Science for Transplant and Cellular Therapy Aichi Medical University School of Medicine Aichi Japan
Japanese Data Center For Hematopoietic Cell Transplantation Aichi Japan
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Deutsche Knochenmarkspenderdatei
Affiliation as printed
DKMS Group Tübingen Germany
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Affiliation as printed
University of Minnesota Medical School Minneapolis USA
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Affiliation as printed
Department of General Surgery, Division of Transplantation Medical University Vienna Vienna Austria
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Affiliation as printed
University of Minnesota Medical School Minneapolis USA
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