Genetic and epigenetic alterations at secondary resistance after continued decitabine-based treatment of acute myeloid leukemia in the randomized phase II DECIDER trial

Leukemia, vol. 39, pp. 2816–2819

Abstract

Therapies containing the hypomethylating agents (HMA) decitabine (DEC) or azacitidine (AZA) are standard of care for patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy. However, initially responsive disease eventually develops secondary resistance [ 1 , 2 , 3 , 4 ].

Authors 18

1. Inga Hund

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

   Faculty of Biology, University of Freiburg, Freiburg, Germany

2. Maria Elena Hess

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Faculty of Biology, University of Freiburg, Freiburg, Germany

   Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

3. Geoffroy Andrieux

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

4. Julia Stomper Aachen Department of Hematology, Oncology

   RWTH Aachen University · Universitätsklinikum Aachen · University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

   Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany

5. Gabriele Greve

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

   Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany

6. Christoph Niemöller

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

7. Tobias Ma

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

8. David Uhl

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

9. Felicitas R. Thol

   Medizinische Hochschule Hannover

   Affiliation as printed

   Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

10. Michael Heuser

    Medizinische Hochschule Hannover · Martin Luther University Halle-Wittenberg · University Hospital in Halle

    Affiliation as printed

    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

    Department of Internal Medicine IV, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany

11. Gesine Bug

    University Hospital Frankfurt · Goethe University Frankfurt

    Affiliation as printed

    Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany

12. Martina Margrit Crysandt Aachen Department of Hematology, Oncology

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany

13. Andreas Neubauer

    Universitätsklinikum Gießen und Marburg

    Affiliation as printed

    Department of Hematology and Oncology, University Clinic Gießen/Marburg, Marburg, Germany

14. Justus Duyster

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany

15. Hartmut Döhner

    University Hospital Ulm

    Affiliation as printed

    Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

16. Melanie Boerries

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany

    Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

17. Michael Lübbert

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany

18. Heiko Becker corresponding

    German Cancer Research Center · University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. heiko.becker@uniklinik-freiburg.de

    German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany. heiko.becker@uniklinik-freiburg.de

    Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany