Photoactive Nanoplatforms with Immunomodulation Effect for Antibacterial Therapy
Advanced Healthcare Materials, vol. 14, pp. e03365
Abstract
The accelerating increase in bacterial resistance to conventional antibiotics is a significant obstacle to the effective management of infectious diseases. Phototherapy is considered as a promising antibacterial strategy because of its non-invasiveness and broad antibacterial spectrum without induction of drug resistance. Unfortunately, single-mode phototherapy may cause thermal damage to surrounding tissue and reactive oxygen species (ROS) have a short half-life, which reduces their therapeutic efficacy. Immunomodulation exhibits distinct superiority in treating bacterial infection by utilizing immune system to actively eradicate pathogens, which also prevents recurrence of bacterial infection. Therefore, designing photoactive nanoplatforms with immunoregulation capacity is a two-pronged approach to achieve an effective antibacterial purpose. In this review, the mechanisms of phototherapy, immunomodulation and their synergy in treating bacterial infections are systematically summarized. Meanwhile, the recent applications of phototherapy coupled with immunomodulation for various infectious diseases are outlined. Moreover, the existing advantages, limitations and prospects for this kind of antibacterial strategy are discussed, aiming to accelerate the advancements and clinical transformation in this area.
Authors 6
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi, 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi, 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi, 214112 P. R. China
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Leibniz Institute of Polymer Research
Affiliation as printed
Leibniz‐Institut für Polymerforschung Dresden e.V. 01069 Dresden Germany
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RWTH Aachen University · Universitätsklinikum Aachen
Affiliation as printed
Institute for Experimental Molecular Imaging Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering RWTH Aachen University 52074 Aachen Germany
Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany
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Wei Wang corresponding
China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi, 214112 P. R. China
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