From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications
Acta Pharmaceutica Sinica B, vol. 16, pp. 1804–1847
Abstract
Microneedles (MNs), as innovative biomedical devices, are undergoing a transformation from basic transdermal devices to intelligent and multifunctional systems. The advancement of intelligent MNs enhances tissue penetration and adhesion, triggers timely, on-demand and precise spatiotemporal controlled release, achieves sequential drug delivery and in situ monitoring, and enables close-loop theranostics via the integration of flexible electronics, wireless communication, and artificial intelligence. This review not only systematically highlights these cutting-edge breakthroughs, focusing on five major innovative advancements of conceptual design, including mimicking strategies, stimuli-responsive systems, innovative structural designs, living payload, and wearable integration, but also delineates the principal obstacles obstructing the advancement of intelligent MNs. We also emphasize that MN technology is fueling the evolution of next-generation medical paradigms based on its personalized, minimally invasive, and intelligent features through interdisciplinary integration, which is crucial for reshaping the future landscape of disease diagnosis and treatment.
Authors 9
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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Zihan Wang corresponding
China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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Jing Shang corresponding
China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen 52074, Germany
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Wei Wang corresponding
China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics, China Pharmaceutical University, Nanjing 211198, China
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Wuxi Research Center for Innovative Medicines and Life Health, Wuxi Innovation Research Institute of China Pharmaceutical University, Wuxi 214112, China
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