Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies
npj Digital Medicine, vol. 8, pp. 493
Abstract
In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.
Authors 43
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Fraunhofer Institute for Cell Therapy and Immunology
Affiliation as printed
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
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Fraunhofer Institute for Cell Therapy and Immunology
Affiliation as printed
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
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Fraunhofer Institute for Algorithms and Scientific Computing
Affiliation as printed
Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin, Germany
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Affiliation as printed
Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany
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Affiliation as printed
Information Technology for Translational Medicine (ITTM) S.A., Esch-sur-Alzette, Luxembourg
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Inserm · Université Paris Sciences et Lettres · École Nationale Supérieure des Mines de Paris · Institut Curie
Affiliation as printed
INSERM, U900, Paris, France
Institut Curie, INSERM, U 1331, Mines Paris Tech, PSL Research University, Paris, France
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Inserm · Université Paris Sciences et Lettres · École Nationale Supérieure des Mines de Paris · Institut Curie
Affiliation as printed
INSERM, U900, Paris, France
Institut Curie, INSERM, U 1331, Mines Paris Tech, PSL Research University, Paris, France
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Affiliation as printed
Institute for Clinical Immunology, University Hospital of Leipzig, Leipzig, Germany
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Affiliation as printed
Department of Hematology, Hemostaseology and Cellular Therapy, University Hospital of Leipzig, Leipzig, Germany
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Affiliation as printed
Myeloma Patients Europe AISBL, Brussels, Belgium
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Affiliation as printed
Myeloma Patients Europe AISBL, Brussels, Belgium
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Fraunhofer Institute for Cell Therapy and Immunology · Center for Scalable Data Analytics and Artificial Intelligence · Leipzig University
Affiliation as printed
Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden/Leipzig, Germany
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
Innovation Center Computer Assisted Surgery, Universität Leipzig, Leipzig, Germany
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Fraunhofer Institute for Cell Therapy and Immunology
Affiliation as printed
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
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Affiliation as printed
TriNetX Oncology GmbH, Freiburg, Germany
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Affiliation as printed
HealthTree Foundation Inc., Lehi, UT, USA
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Affiliation as printed
CREATIC, Faculty of Medicine, Masaryk University, Brno, Czechia
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Affiliation as printed
CREATIC, Faculty of Medicine, Masaryk University, Brno, Czechia
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Utrecht University · University Medical Center Utrecht
Affiliation as printed
Center for Translational Immunology and Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
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Jurgen H. E. Kuball Aachen
Utrecht University · University Medical Center Utrecht · European Society for Blood and Marrow Transplantation · European Society for Blood and Marrow Transplantation
Affiliation as printed
Cellular Therapy and Immunobiology Working Party (CTIWP) of the European Society for Blood and Marrow Transplantation (EBMT), Leiden, The Netherlands
Center for Translational Immunology and Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
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Affiliation as printed
Research Center Information, Law and Society, University of Namur, Namur, Belgium
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Affiliation as printed
Research Center Information, Law and Society, University of Namur, Namur, Belgium
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Fraunhofer Institute for Cell Therapy and Immunology · Center for Scalable Data Analytics and Artificial Intelligence · Leipzig University
Affiliation as printed
Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden/Leipzig, Germany
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
Institute for Drug Discovery, Faculty of Medicine, Leipzig University, Leipzig, Germany
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University Hospital Leipzig · Fraunhofer Institute for Cell Therapy and Immunology
Affiliation as printed
Department of Hematology, Hemostaseology and Cellular Therapy, University Hospital of Leipzig, Leipzig, Germany
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
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Affiliation as printed
Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany
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Vaclovas Radvilas Aachen
European Society for Blood and Marrow Transplantation · European Society for Blood and Marrow Transplantation
Affiliation as printed
European Society for Blood and Marrow Transplantation (EBMT), Leiden, The Netherlands
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European Society for Blood and Marrow Transplantation · University Medical Center Hamburg-Eppendorf · European Society for Blood and Marrow Transplantation
Affiliation as printed
Chronic Malignancy Working Party, Multiple Myeloma Sub-committee Chair CAR-T, of the European Society for Blood and Marrow Transplantation (EBMT), Leiden, The Netherlands
Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Humboldt-Universität zu Berlin · Freie Universität Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Hematology, Oncology and Tumorimmunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
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Fraunhofer Institute for Cell Therapy and Immunology · Klinikum Chemnitz
Affiliation as printed
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
Medicine Campus MEDiC of the Dresden University of Technology at Klinikum Chemnitz gGmbH, Chemnitz, Germany
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Affiliation as printed
F. Hoffmann-LaRoche AG, Basel, Switzerland
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Affiliation as printed
Collaborate Project Management, Munich, Germany
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Affiliation as printed
Research Center Information, Law and Society, University of Namur, Namur, Belgium
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Centre National de la Recherche Scientifique · Institut national de recherche en sciences et technologies du numérique · Université Toulouse III - Paul Sabatier · Université de Toulouse · Unité de biologie Moléculaire, Cellulaire et du Développement · Centre de Biologie Intégrative de Toulouse
Affiliation as printed
Lifeware Group, Inria, Paris, France
Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, UPS, CNRS, Toulouse, France
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Sorbonne Université · Assistance Publique – Hôpitaux de Paris · Pitié-Salpêtrière Hospital
Affiliation as printed
Hematology and Cellular Therapy Department, Hopital Pitié Salpêtrière APHP, Sorbonne Université, Paris, France
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Universitätsklinikum Würzburg · Fraunhofer Institute for Cell Therapy and Immunology
Affiliation as printed
Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany
Fraunhofer Institute for Cell Therapy and Immunology IZI, Cellular Immunotherapy Branch Site Würzburg, Würzburg, Germany
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Center for Scalable Data Analytics and Artificial Intelligence · Leipzig University
Affiliation as printed
Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden/Leipzig, Germany
Innovation Center Computer Assisted Surgery, Universität Leipzig, Leipzig, Germany
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Affiliation as printed
Department of Hematology, Hemostaseology and Cellular Therapy, University Hospital of Leipzig, Leipzig, Germany
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University Hospital Leipzig · Fraunhofer Institute for Cell Therapy and Immunology · Center for Scalable Data Analytics and Artificial Intelligence
Affiliation as printed
Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden/Leipzig, Germany
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
Institute for Clinical Immunology, University Hospital of Leipzig, Leipzig, Germany
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Affiliation as printed
CREATIC, Faculty of Medicine, Masaryk University, Brno, Czechia
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Affiliation as printed
Information Technology for Translational Medicine (ITTM) S.A., Esch-sur-Alzette, Luxembourg
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Affiliation as printed
Innovation Center Computer Assisted Surgery, Universität Leipzig, Leipzig, Germany
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University of Bonn · Fraunhofer Institute for Algorithms and Scientific Computing · Bonn Aachen International Center for Information Technology
Affiliation as printed
Bonn-Aachen International Center for IT (b-it), University of Bonn, Bonn, Germany
Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin, Germany
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Memorial Sloan Kettering Cancer Center · University Hospital Leipzig · Fraunhofer Institute for Cell Therapy and Immunology
Affiliation as printed
Department of Hematology, Hemostaseology and Cellular Therapy, University Hospital of Leipzig, Leipzig, Germany
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, USA
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Kristin Reiche corresponding
University Hospital Leipzig · Fraunhofer Institute for Cell Therapy and Immunology · Center for Scalable Data Analytics and Artificial Intelligence
Affiliation as printed
Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden/Leipzig, Germany. kristin.reiche@izi.fraunhofer.de
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany. kristin.reiche@izi.fraunhofer.de
Institute for Clinical Immunology, University Hospital of Leipzig, Leipzig, Germany. kristin.reiche@izi.fraunhofer.de
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