CADET-Core 5.0: High-Performance Solver for Advanced Biotechnology Process Modeling
The Journal of Open Source Software, vol. 10, pp. 7881
Abstract
Biotechnology process modeling integrates detailed scientific insight into mass transfer phenomena and phase transitions with the practical demands of industrial process design and optimization.CADET-Core is an open-source software platform offering powerful tools for comprehensive modeling and simulation of biotechnology processes, powered by state-of-the-art numerical algorithms.Originally developed in 2004 at Forschungszentrum Jülich for chromatography simulation (von Lieres & Andersson, 2010), CADET-Core has since evolved into a versatile tool serving a wide range of biotechnology applications.CADET-Core supports unit operations such as chromatography, filtration, and crystallization, along with auxiliary components such as hold tanks, tubes, valves, and detectors.These elements can be interconnected to form complex networks, supporting closed-loop feedback and flexible structures.The modular design and computational efficiency of CADET-Core enable simulation and advanced optimization of such processes.
Authors 9
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Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
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Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
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Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
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Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
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Hannah Lanzrath Aachen
Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
RWTH Aachen University, Computational Systems Biotechnology, Aachen, 52074, Germany
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Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
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Rensselaer Polytechnic Institute
Affiliation as printed
Rensselaer Polytechnic Institute, Department of Chemical and Biological Engineering, Troy, 12180, New York, United States of America
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Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
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Eric von Lieres Aachen
Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Forschungszentrum Jülich, IBG-1: Biotechnology, Jülich, 52428, Germany
RWTH Aachen University, Computational Systems Biotechnology, Aachen, 52074, Germany
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