Reply to: “Statins in MASLD: Challenges and future directions”

JHEP Reports, vol. 7, pp. 101490

Abstract

We thank Dr. Zheng and co-authors for their Letter to the Editor, as we fully agree that the long-term effects of statins on liver health deserve further evaluation, especially in elderly populations. We would additionally suggest leveraging real-world evidence (RWE) to evaluate the long-term effects and safety in elderly populations, and for example to investigate specific subgroups (1), since starting new large-scale trials which only evaluate statins might not be feasible and/or warranted. In our post-hoc analysis of the PROSPER trial, indeed no detailed safety data was available.

Authors 5

1. Vivian de Jong corresponding

   University Medical Center Utrecht · Utrecht University · Julius Clinical Research BV (Netherlands)

   Affiliation as printed

   Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

   Julius Clinical, Zeist, the Netherlands

2. Stella Trompet Aachen Department of Cardiology, Leiden University Medical Centre Department of Internal Medicine section Gerontology and Geriatrics

   Leiden University · Leiden University Medical Center · Netherlands Heart Institute

   Affiliation as printed

   Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands

   Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands

   Netherlands Heart Institute, Utrecht, the Netherlands

3. J. Wouter Jukema Aachen Department of Cardiology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands

4. Diederick E. Grobbee

   University Medical Center Utrecht · Utrecht University · Julius Clinical Research BV (Netherlands)

   Affiliation as printed

   Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

   Julius Clinical, Zeist, the Netherlands

5. Manuel Castro Cabezas

   Erasmus MC · Sint Franciscus Gasthuis · Julius Clinical Research BV (Netherlands)

   Affiliation as printed

   Department of Endocrinology, Erasmus MC Medical Center, Rotterdam, the Netherlands

   Department of Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands

   Julius Clinical, Zeist, the Netherlands