Access to N ‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives

Angewandte Chemie International Edition, vol. 64, pp. e202505478

Abstract

Abstract This work presents the first general synthetic access to N ‐CH₂F and N ‐CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds. The synthetic approach employs N ‐CH 2 F and N ‐CHRF carbamoyl fluorides as versatile strategic building blocks, which can be efficiently synthesized in a single step directly from readily available amines or imines.

Authors 4

1. Filip G. Zivkovic Aachen Institute of Organic Chemistry

   RWTH Aachen University

   Affiliation as printed

   Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany

   RWTH Aachen: Rheinisch-Westfalische Technische Hochschule Aachen Chemistry GERMANY

2. Fritz Bahns Aachen Institute of Organic Chemistry

   RWTH Aachen University

   Affiliation as printed

   Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany

   RWTH Aachen: Rheinisch-Westfalische Technische Hochschule Aachen Chemistry GERMANY

3. Che-Ming Hsu Aachen Institute of Organic Chemistry

   RWTH Aachen University

   Affiliation as printed

   Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany

   RWTH Aachen: Rheinisch-Westfalische Technische Hochschule Aachen Chemistry GERMANY

4. Franziska Schoenebeck corresponding Aachen Institute of Organic Chemistry

   RWTH Aachen University

   Affiliation as printed

   Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany

   RWTH Aachen University Landoltweg 1 52074 Aachen GERMANY