Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model

JACC Basic to Translational Science, vol. 10, pp. 101221

Abstract

Sixteen sheep with ischemic chronic heart failure were randomized to either 3 months of Impella 5.5 support (Abiomed) or sham. Myocardial reverse remodeling by Impella support was shown by a significant reduction of end-diastolic volume (Impella 22% reduction, and control 5% increase; P = 0.011) and end-systolic volume (Impella 20% reduction, and control 11% increase; P = 0.011). Functional measurements demonstrated improved regional ejection fraction and wall thickening in the viable myocardium of hearts supported with Impella. Supported animals had a significant decrease in wall volume, with less cardiomyocyte hypertrophy than control subjects.

Authors 9

1. Bart P. Meyns corresponding

   KU Leuven

   Affiliation as printed

   Department Cardiac Surgery, KULeuven, Leuven, Belgium. Electronic address: Bart.meyns@uzleuven.be

2. Randi J. Parks Aachen Academic and Pre-Clinical Research

   Abiomed (Germany)

   Affiliation as printed

   Academic and Pre-Clinical Research, Abiomed, Inc, Aachen, Germany

3. Erik K. Verbeken

   KU Leuven

   Affiliation as printed

   Department of Pathology, KULeuven, Leuven, Belgium

4. Manon Van Hecke

   KU Leuven

   Affiliation as printed

   Department of Pathology, KULeuven, Leuven, Belgium

5. Steven Jacobs

   KU Leuven

   Affiliation as printed

   Department Cardiac Surgery, KULeuven, Leuven, Belgium

6. Magdalena Sikole

   KU Leuven

   Affiliation as printed

   Department Cardiac Surgery, KULeuven, Leuven, Belgium

7. Charlotte J. Van Edom

   KU Leuven

   Affiliation as printed

   Department of Cardiovascular Sciences, KULeuven, Leuven, Belgium

8. Eveline Bennek Schoepping Aachen Academic and Pre-Clinical Research

   Abiomed (Germany)

   Affiliation as printed

   Academic and Pre-Clinical Research, Abiomed, Inc, Aachen, Germany

9. Piet Claus

   KU Leuven

   Affiliation as printed

   Department of Cardiovascular Imaging, KULeuven, Leuven, Belgium