IgG Glycosylation: Biomarker, Functional Modulator, and Structural Component

• Longitudinal Maternal IgG and IgA Glycosylation Profiles in Pregnancy Reveal Early Immune Alterations in Placenta-Related Complications: The Rotterdam Periconception Cohort

  2026 Hypertension article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access

  0

  citations
• The glycan fingerprint in immune thrombocytopenia

  2026 Research and Practice in Thrombosis and Haemostasis article Medicine Platelet Disorders and Treatments Open access

  0

  citations
• Decreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young children

  2025 Communications Medicine article Medicine Respiratory viral infections research Open access

  1

  citations

3 results

• Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

  2020 Science article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 2 patents

  415

  citations
• High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

  2021 Science Translational Medicine article Medicine SARS-CoV-2 and COVID-19 Research Open access cited by 2 patents

  283

  citations
• The unique properties of IgG4 and its roles in health and disease

  2023 Nature reviews. Immunology review Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 7 patents

  264

  citations
• Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

  2020 Science Advances article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access

  146

  citations
• Glycobiology of rheumatic diseases

  2022 Nature Reviews Rheumatology review Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access

  102

  citations
• Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation

  2021 The Journal of Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 1 patent

  88

  citations
• Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation

  2022 Science Advances article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access

  77

  citations
• Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

  2022 EBioMedicine article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access

  69

  citations
• IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants

  2020 Journal of Allergy and Clinical Immunology article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access

  67

  citations
• Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

  2021 Nature Communications article Medicine Malaria Research and Control Open access

  62

  citations
• Factors affecting IgG4-mediated complement activation

  2023 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access

  56

  citations
• Antibody Subclass and Glycosylation Shift Following Effective TB Treatment

  2021 Frontiers in Immunology article Medicine Tuberculosis Research and Epidemiology Open access

  56

  citations
• IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross‐Sectional Study Encompassing ~1,500 Samples

  2022 Arthritis & Rheumatology article Medicine Rheumatoid Arthritis Research and Therapies Open access

  56

  citations
• The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

  2022 EBioMedicine article Medicine SARS-CoV-2 and COVID-19 Research Open access

  42

  citations
• Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

  2020 mAbs article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 2 patents

  42

  citations
• Natural killer cell activation by respiratory syncytial virus‐specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc‐glycosylation

  2020 Clinical & Translational Immunology article Medicine Respiratory viral infections research Open access

  37

  citations
• Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

  2023 iScience article Medicine SARS-CoV-2 and COVID-19 Research Open access

  24

  citations
• IgG Fab Glycans Hinder FcRn-Mediated Placental Transport

  2023 The Journal of Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access

  23

  citations
• Distinct glycosylation and functional profile of typhoid vaccine-induced antibodies in a UK challenge study and Nepalese children

  2022 Frontiers in Analytical Science article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access

  3

  citations
• Author Correction: Human DC-SIGN and CD23 do not interact with human IgG

  2020 Scientific Reports erratum Immunology and Microbiology Immunotherapy and Immune Responses Open access

  2

  citations

20 results