Emerging biotechnologies for engineering liver organoids

• Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing

  2020 Nature Cell Biology article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 15 patents

  300

  citations
• Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

  2023 Nature Biotechnology article Medicine Liver Disease Diagnosis and Treatment Open access cited by 1 patent

  248

  citations
• Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver

  2020 Nature Protocols article Medicine Liver physiology and pathology Open access cited by 1 patent

  159

  citations
• Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

  2020 Cell Systems article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 1 patent

  110

  citations
• Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss

  2023 Nature Communications article Medicine Hepatocellular Carcinoma Treatment and Prognosis Open access

  34

  citations
• Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures

  2023 Nature Communications article Medicine Malaria Research and Control Open access

  34

  citations

6 results