Right Ventricular Restrictive Physiology Is Associated With Right Ventricular Direct Flow From 4D Flow CMR

JACC Asia, vol. 4, pp. 912–924

Abstract

Background: Right ventricular restrictive physiology (RVRP) is a common occurrence in repaired tetralogy of Fallot (rTOF). The relationship of RVRP with biventricular blood flow components and kinetic energy (KE) from 4-dimensional (4D) flow cardiovascular magnetic resonance (CMR) is unclear. Objectives: The purpose of this study was to investigate the association of 4D flow CMR parameters with RVRP in rTOF patients. Methods: ) were analyzed encompassing global, peak systolic, average systolic, average diastolic, peak E-wave, and peak A-wave. Results: < 0.001). Conclusions: RVRP is associated with dilated RV, higher pulmonary regurgitation, and higher RV direct flow. (Integrated Computational modeling of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease; NCT03217240).

Authors 15

1. Xiaodan Zhao corresponding

   National Heart Centre Singapore

   Affiliation as printed

   National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore

2. Phong Teck Lee corresponding

   National Heart Centre Singapore

   Affiliation as printed

   National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore

3. Liwei Hu

   Duke-NUS Medical School

   Affiliation as printed

   Duke-NUS Medical School, Singapore

4. Ru‐San Tan

   Shanghai Jiao Tong University · Shanghai Children's Medical Center · National Heart Centre Singapore

   Affiliation as printed

   Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

   National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore

5. Ping Chai

   National University of Singapore · National University Hospital

   Affiliation as printed

   National University Hospital Singapore, Singapore

   Yong Loo Lin School of Medicine, National University of Singapore, Singapore

6. Tee Joo Yeo

   National University of Singapore · National University Hospital

   Affiliation as printed

   National University Hospital Singapore, Singapore

   Yong Loo Lin School of Medicine, National University of Singapore, Singapore

7. Shuang Leng

   Shanghai Jiao Tong University · Shanghai Children's Medical Center · National Heart Centre Singapore

   Affiliation as printed

   Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

   National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore

8. Rongzhen Ouyang

   Duke-NUS Medical School

   Affiliation as printed

   Duke-NUS Medical School, Singapore

9. Jennifer Bryant

   Shanghai Jiao Tong University · Shanghai Children's Medical Center · National Heart Centre Singapore

   Affiliation as printed

   Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

   National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore

10. Lynette Teo

    National University of Singapore · National University Hospital

    Affiliation as printed

    National University Hospital Singapore, Singapore

    Yong Loo Lin School of Medicine, National University of Singapore, Singapore

11. Rob J. van der Geest Aachen Department of Radiology, Leiden University Medical Center

    Leiden University Medical Center

    Affiliation as printed

    Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands

12. James Yip

    National University of Singapore · National University Hospital

    Affiliation as printed

    National University Hospital Singapore, Singapore

    Yong Loo Lin School of Medicine, National University of Singapore, Singapore

13. Ju Le Tan

    Shanghai Jiao Tong University · Shanghai Children's Medical Center · National Heart Centre Singapore

    Affiliation as printed

    Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore

14. Yumin Zhong corresponding

    Duke-NUS Medical School

    Affiliation as printed

    Duke-NUS Medical School, Singapore

15. Liang Zhong corresponding

    National University of Singapore · Shanghai Jiao Tong University · Shanghai Children's Medical Center · National Heart Centre Singapore

    Affiliation as printed

    Department of Biomedical Engineering, National University of Singapore, Singapore

    Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore