Stellabody: A novel hexamer‐promoting mutation for improved IgG potency

• Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches

  2024 Seminars in Immunology article Immunology and Microbiology Complement system in diseases Open access

  18

  citations

1 result

• DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

  2020 Blood Cancer Journal article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 5 patents

  71

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• C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases

  2021 Proceedings of the National Academy of Sciences article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent

  62

  citations
• Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism

  2020 Molecular Cancer Therapeutics article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 9 patents

  54

  citations
• Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

  2023 Nature Communications article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents

  50

  citations
• Logic-gated antibody pairs that selectively act on cells co-expressing two antigens

  2022 Nature Biotechnology article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 7 patents

  49

  citations
• Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities

  2022 Journal of Pharmaceutical Sciences article Medicine Monoclonal and Polyclonal Antibodies Research Open access

  13

  citations

6 results