The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report
eNeuro, vol. 11, pp. ENEURO.0191–24.2024
Abstract
Conscious reportability of visual input is associated with a bimodal neural response in the primary visual cortex (V1): an early-latency response coupled to stimulus features and a late-latency response coupled to stimulus report or detection. This late wave of activity, central to major theories of consciousness, is thought to be driven by the prefrontal cortex (PFC), responsible for "igniting" it. Here we analyzed two electrophysiological studies in mice performing different stimulus detection tasks and characterized neural activity profiles in three key cortical regions: V1, posterior parietal cortex (PPC), and PFC. We then developed a minimal network model, constrained by known connectivity between these regions, reproducing the spatiotemporal propagation of visual- and report-related activity. Remarkably, while PFC was indeed necessary to generate report-related activity in V1, this occurred only through the mediation of PPC. PPC, and not PFC, had the final veto in enabling the report-related late wave of V1 activity.
Authors 7
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Affiliation as printed
Institute for Theoretical Physics, Utrecht University, Utrecht 3584CC, Netherlands
Institute for Theoretical Physics, Utrecht University, Utrecht, 3584CC, The Netherlands
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Affiliation as printed
Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, Netherlands
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1098XH, The Netherlands
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, 1098XH, The Netherlands
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Leiden University · University of Amsterdam
Affiliation as printed
Korteweg-de Vries Institute for Mathematics, University of Amsterdam, Amsterdam 1098XG, Netherlands
Mathematical Institute, Leiden University, Leiden 2333CA, Netherlands
Korteweg-de Vries Institute for Mathematics, University of Amsterdam, Science Park 105-107, 1098XG, Amsterdam, The Netherlands
Mathematical Institute, Leiden University, Niels Borhweg 1, 2333CA, Leiden, The Netherlands
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Affiliation as printed
Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, Netherlands
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1098XH, The Netherlands
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, 1098XH, The Netherlands
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Amsterdam Neuroscience · Vrije Universiteit Amsterdam · Centre Inria d'Université Côte d'Azur
Affiliation as printed
Amsterdam Center for Dynamics and Computation, Mathematics Department, Vrije Universiteit Amsterdam, Amsterdam 1081HV, Netherlands d.avitabile@vu.nl s.vangaal@uva.nl u.olcese@uva.nl
Amsterdam Neuroscience, Systems and Network Neuroscience, Amsterdam 1081HV, Netherlands
Mathneuro Team, Inria Centre at Université Côte d'Azur, Sophia Antipolis 06902, France
Amsterdam Center for Dynamics and Computation, Mathematics Department, Vrije Universiteit Amsterdam, Amsterdam, 1081HV, The Netherlands. d.avitabile@vu.nl s.vangaal@uva.nl u.olcese@uva.nl
Amsterdam Neuroscience, Systems and Network Neuroscience, Amsterdam, 1081HV, The Netherlands
Mathneuro Team, Inria Centre at Université Côte d'Azur, Sophia Antipolis, 06902, France
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Affiliation as printed
Department of Psychology, University of Amsterdam, Amsterdam 1018WT, Netherlands
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands d.avitabile@vu.nl s.vangaal@uva.nl u.olcese@uva.nl
Department of Psychology, University of Amsterdam, Amsterdam, 1018WT, The Netherlands
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, 1098XH, The Netherlands. d.avitabile@vu.nl s.vangaal@uva.nl u.olcese@uva.nl
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University of Amsterdam · Centre Inria d'Université Côte d'Azur
Affiliation as printed
Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, Netherlands d.avitabile@vu.nl s.vangaal@uva.nl u.olcese@uva.nl
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1098XH, The Netherlands. d.avitabile@vu.nl s.vangaal@uva.nl u.olcese@uva.nl
Mathneuro Team, Inria Centre at Université Côte d'Azur, Sophia Antipolis, 06902, France
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, 1098XH, The Netherlands
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