Bioinspired active hemocompatible coating systems for mechanical circulatory support devices: when engineering meets nano and molecular technology

Procedia CIRP, vol. 125, pp. 60–65

Abstract

Industrial manufacturing is undergoing a biological transformation, which has become a growing part of current research in production engineering. The technologies involved help to translate innovative approaches into existing or novel medical devices. Currently, however, even the most advanced blood contacting medical devices fail to be sufficiently inert to blood, thus causing acute effects – coagulation, inflammation, embolism, stroke – as well as chronic ones – inflammation and chronic use of anticoagulants. We present the marriage of advanced molecular science, nanotechnology and advanced production engineering to improve the hemocompatibility of hemodynamic systems, such as artificial hearts. Our consortium has joined forces to develop nature-inspired coating systems that improve hemocompatibility, prohibit adhesion of bacteria and minimize the growth of dangerous large thrombi. We achieve this by (1) concealing the presence of the titanium surface, thereby minimizing the activation of inflammatory and coagulatory reactions, (2) locally inactivating those molecules that cause uncontrolled coagulation, (3) directing the blood to use its own fibrinolytic system to digest the clot and (4) introducing micro surface patterns that interfere with the flow near the surface generating shear, which in turn prohibits dangerous clots from growing. In vitro tests demonstrate considerable improvement in hemocompatibility.

Authors 10

1. Martin Kohse corresponding Aachen Fraunhofer Institute for Production Technology IPT

   Fraunhofer Institute for Production Technology IPT

   Affiliation as printed

   Fraunhofer Institute for Production Technology IPT, Steinbachstr. 17, 52074 Aachen, Germany

2. Lena Witzdam Aachen DWI – Lebniz Institute for Interactive Materials e.V

   DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI – Lebniz Institute for Interactive Materials e.V., Forckenbeckstraße 50, 52074 Aachen, Germany

3. Felix Jakob Aachen DWI – Lebniz Institute for Interactive Materials e.V

   DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI – Lebniz Institute for Interactive Materials e.V., Forckenbeckstraße 50, 52074 Aachen, Germany

4. Alexander Boes Aachen DWI – Lebniz Institute for Interactive Materials e.V

   DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI – Lebniz Institute for Interactive Materials e.V., Forckenbeckstraße 50, 52074 Aachen, Germany

5. Holger Mescheder Aachen Fraunhofer Institute for Production Technology IPT

   Fraunhofer Institute for Production Technology IPT

   Affiliation as printed

   Fraunhofer Institute for Production Technology IPT, Steinbachstr. 17, 52074 Aachen, Germany

6. Robin Day Aachen Fraunhofer Institute for Production Technology IPT

   Fraunhofer Institute for Production Technology IPT

   Affiliation as printed

   Fraunhofer Institute for Production Technology IPT, Steinbachstr. 17, 52074 Aachen, Germany

7. Oliver Grottke Aachen Department of Anesthesiology

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany

8. Ulrich Schwaneberg Aachen Chair of Biotechnology DWI – Lebniz Institute for Interactive Materials e.V

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   Chair of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany

   DWI – Lebniz Institute for Interactive Materials e.V., Forckenbeckstraße 50, 52074 Aachen, Germany

9. César Rodriguez‐Emmenegger Aachen DWI – Lebniz Institute for Interactive Materials e.V

   DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI – Lebniz Institute for Interactive Materials e.V., Forckenbeckstraße 50, 52074 Aachen, Germany

10. Thomas Bergs Aachen Fraunhofer Institute for Production Technology IPT Laboratory for Machine Tools and Production Engineering (WZL)

    Fraunhofer Institute for Production Technology IPT · RWTH Aachen University

    Affiliation as printed

    Fraunhofer Institute for Production Technology IPT, Steinbachstr. 17, 52074 Aachen, Germany

    Laboratory for Machine Tools and Production Engineering (WZL) of RWTH Aachen University, Campus Boulevard 30, 52074 Aachen, Germany