Vaccine value profile for schistosomiasis
Vaccine, vol. 64, pp. 126020
Abstract
Schistosomiasis is caused by parasitic flatworms (Schistosoma). The disease in humans can be caused by seven different species of Schistosoma: S. mansoni, S. japonicum, S. haematobium, S. malayensis, S. mekongi, S. guineensis and S. intercalatum, as well as by hybrids between species, including livestock schistosome species. People are infected when exposed to infested water and the parasite larvae penetrate the skin. Poor and rural communities are typically the most affected, and the general population who lives in affected areas and is exposed to contaminated water is at risk. Areas with poor access to safe water and adequate sanitation are also at heightened risk. About 236.6 million people required treatment for schistosomiasis in 2019-mostly people living in poor, rural communities, especially fishing and agricultural communities. This 'Vaccine Value Profile' (VVP) for schistosomiasis is intended to provide a high-level, holistic assessment of the information and data that are currently available to inform the potential public health, economic, and societal value of pipeline vaccines and vaccine-like products. This VVP was developed by a working group of subject matter experts from academia, non-profit organizations, public private partnerships, and multi-lateral organizations. All contributors have extensive expertise on various elements of the schistosomiasis VVP and collectively aimed to identify current research and knowledge gaps. The VVP was developed using only existing and publicly available information.
Authors 17
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Gavin Yamey corresponding
Affiliation as printed
Duke Global Health Institute, Duke University, Durham, NC, United States. Electronic address: gavin.yamey@duke.edu
Duke Global Health Institute, Duke University, Durham, NC, United States
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Affiliation as printed
Duke Global Health Institute, Duke University, Durham, NC, United States. Electronic address: kaci.kennedy.mcdade@duke.edu
Duke Global Health Institute, Duke University, Durham, NC, United States
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Affiliation as printed
Faculty of Medicine, School of Public Health, Imperial College London, London, United Kingdom. Electronic address: roy.anderson@imperial.ac.uk
Faculty of Medicine, School of Public Health, Imperial College London, London, United Kingdom
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City University of New York · CUNY Graduate School of Public Health and Health Policy
Affiliation as printed
Public Health Informatics, Computational, and Operations Research and Center for Advanced Technology and Communication in Health, City University of New York Graduate School of Public Health and Health Policy, New York City, NY, United States. Electronic address: sbartsch1029@gmail.com
Public Health Informatics, Computational, and Operations Research and Center for Advanced Technology and Communication in Health, City University of New York Graduate School of Public Health and Health Policy, New York City, NY, United States
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Baylor College of Medicine · Texas Children's Hospital
Affiliation as printed
National School of Tropical Medicine, Baylor College of Medicine, Texas Children's Hospital Center for Vaccine Development, Houston, TX, United States. Electronic address: bottazzi@bcm.edu
National School of Tropical Medicine, Baylor College of Medicine, Texas Children's Hospital Center for Vaccine Development, Houston, TX, United States
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Affiliation as printed
School of Medicine and Health Sciences, George Washington University, Washington, D.C., United States. Electronic address: ddiemert@gwu.edu
School of Medicine and Health Sciences, George Washington University, Washington, D.C., United States
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Baylor College of Medicine · Texas Children's Hospital
Affiliation as printed
National School of Tropical Medicine, Baylor College of Medicine, Texas Children's Hospital Center for Vaccine Development, Houston, TX, United States. Electronic address: hotez@bcm.edu
National School of Tropical Medicine, Baylor College of Medicine, Texas Children's Hospital Center for Vaccine Development, Houston, TX, United States
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City University of New York · CUNY Graduate School of Public Health and Health Policy
Affiliation as printed
Public Health Informatics, Computational, and Operations Research and Center for Advanced Technology and Communication in Health, City University of New York Graduate School of Public Health and Health Policy, New York City, NY, United States. Electronic address: bruceleemdmba@gmail.com
Public Health Informatics, Computational, and Operations Research and Center for Advanced Technology and Communication in Health, City University of New York Graduate School of Public Health and Health Policy, New York City, NY, United States
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QIMR Berghofer Medical Research Institute
Affiliation as printed
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: Don.McManus@qimrberghofer.edu.au
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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Affiliation as printed
Department of Microbiology & Immunology, Midwestern University, Glendale, AZ, United States. Electronic address: amoleh@midwestern.edu
Department of Microbiology & Immunology, Midwestern University, Glendale, AZ, United States
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Meta Roestenberg Aachen
Leiden University · Leiden University Medical Center
Affiliation as printed
Leiden University Medical Centre, Leiden, Netherlands. Electronic address: M.Roestenberg@lumc.nl
Leiden University Medical Centre, Leiden, Netherlands
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Affiliation as printed
Global Schistosomiasis Alliance, London, United Kingdom. Electronic address: d.rollinson@nhm.ac.uk
Global Schistosomiasis Alliance, London, United Kingdom
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Texas Tech University · Texas Tech University Health Sciences Center
Affiliation as printed
Center for Tropical Medicine & Infectious Diseases, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, United States. Electronic address: Afzal.Siddiqui@ttuhsc.edu
Center for Tropical Medicine & Infectious Diseases, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, United States
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Affiliation as printed
Laboratory of Research and Development of Anti-Helminth Vaccines, Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, Brazil. Electronic address: tendlermiriam@gmail.com
Laboratory of Research and Development of Anti-Helminth Vaccines, Oswaldo Cruz Institute (Fiocruz), Rio de Janeiro, Brazil
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University of London · Royal Veterinary College
Affiliation as printed
Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, United Kingdom. Electronic address: jowebster@rvc.ac.uk
Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, United Kingdom
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QIMR Berghofer Medical Research Institute
Affiliation as printed
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: Hong.You@qimrberghofer.edu.au
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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International Vaccine Institute
Affiliation as printed
International Vaccine Institute, Seoul, Korea. Electronic address: raphael.zellweger@ivi.int
International Vaccine Institute, Seoul, Korea
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