Towards a seamless product and process development workflow for recombinant proteins produced by plant molecular farming

• An integrated automated pipeline for cloning, transient expression, and purification augmenting the plant cell pack platform for biopharmaceutical screening

  2026 New Biotechnology article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  0

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1 result

• Molecular farming – The slope of enlightenment

  2020 Biotechnology Advances article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications

  181

  citations
• On the verge of the market – Plant factories for the automated and standardized production of biopharmaceuticals

  2020 Biotechnology Advances article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access cited by 2 patents

  93

  citations
• The Emergency Response Capacity of Plant-Based Biopharmaceutical Manufacturing-What It Is and What It Could Be

  2020 Frontiers in Plant Science article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  78

  citations
• Robot Cookies – Plant Cell Packs as an Automated High-Throughput Screening Platform Based on Transient Expression

  2020 Frontiers in Bioengineering and Biotechnology article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  53

  citations
• The use of predictive models to develop chromatography-based purification processes

  2022 Frontiers in Bioengineering and Biotechnology article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access

  51

  citations
• Targeted genome editing of plants and plant cells for biomanufacturing

  2021 Transgenic Research article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  50

  citations
• Scaling eukaryotic cell‐free protein synthesis achieved with the versatile and high‐yielding tobacco BY‐2 cell lysate

  2023 Biotechnology and Bioengineering article Biochemistry, Genetics and Molecular Biology Viral Infectious Diseases and Gene Expression in Insects Open access cited by 1 patent

  42

  citations
• Simple plant‐based production and purification of the assembled human ferritin heavy chain as a nanocarrier for tumor‐targeted drug delivery and bioimaging in cancer therapy

  2022 Biotechnology and Bioengineering article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  30

  citations
• A combined pH and temperature precipitation step facilitates the purification of tobacco‐derived recombinant proteins that are sensitive to extremes of either parameter

  2020 Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  28

  citations
• Killer to cure: Expression and production costs calculation of tobacco plant‐made cancer‐immune checkpoint inhibitors

  2023 Plant Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  28

  citations
• Nicotiana spp. for the Expression and Purification of Functional IgG3 Antibodies Directed Against the Staphylococcus aureus Alpha Toxin

  2021 Frontiers in Chemical Engineering book-review Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  19

  citations
• Design, optimization, production and activity testing of recombinant immunotoxins expressed in plants and plant cells for the treatment of monocytic leukemia

  2023 Bioengineered article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  14

  citations
• The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy

  2022 Plant Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  12

  citations
• Optimizing interleukin-6 and 8 expression, clarification and purification in plant cell packs and plants for application in advanced therapy medicinal products and cellular agriculture

  2024 Journal of Biotechnology article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  11

  citations
• Expression of Biofilm-Degrading Enzymes in Plants and Automated High-Throughput Activity Screening Using Experimental Bacillus subtilis Biofilms

  2021 Frontiers in Bioengineering and Biotechnology article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  10

  citations
• Reducing water uptake into BY‐2 cells by systematically optimizing the cultivation parameters increases product yields achieved by transient expression in plant cell packs

  2022 Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access cited by 1 patent

  10

  citations
• Simulation and optimization of nutrient uptake and biomass formation using a multi-parameter Monod-type model of tobacco BY-2 cell suspension cultures in a stirred-tank bioreactor

  2023 Frontiers in Plant Science article Biochemistry, Genetics and Molecular Biology Plant tissue culture and regeneration Open access

  8

  citations
• Risk assessment and bioburden evaluation of Agrobacterium tumefaciens-mediated transient protein expression in plants using the CaMV35S promoter

  2023 BMC Biotechnology article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  7

  citations
• Membrane-based inverse-transition purification facilitates a rapid isolation of various spider-silk elastin-like polypeptide fusion proteins from extracts of transgenic tobacco

  2024 Transgenic Research article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  7

  citations
• Extraction and purification of malaria vaccine candidate CLCT produced by transient expression in Nicotiana benthamiana plants

  2023 Discover Chemical Engineering article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access

  6

  citations