Functional and structural maturation of auditory cortex from 2 months to 2 years old
bioRxiv (Cold Spring Harbor Laboratory)
Abstract
In school-age children, the myelination of the auditory radiation thalamocortical pathway is associated with the latency of auditory evoked responses, with the myelination of thalamocortical axons facilitating the rapid propagation of acoustic information. Little is known regarding this auditory system function-structure association in infants and toddlers. The present study tested the hypothesis that maturation of auditory radiation white-matter microstructure (e.g., fractional anisotropy (FA); measured using diffusion-weighted MRI) is associated with the latency of the infant auditory response (P2m measured using magnetoencephalography, MEG) in a cross-sectional (2 to 24 months) as well as longitudinal cohort (2 to 29 months) of typically developing infants and toddlers. In the cross-sectional sample, non-linear maturation of P2m latency and auditory radiation diffusion measures were observed. After removing the variance associated with age in both P2m latency and auditory radiation diffusion measures, auditory radiation still accounted for significant variance in P2m latency. In the longitudinal sample, latency and FA associations could be observed at the level of a single child. Findings provide strong support for a contribution of auditory radiation white matter to rapid cortical auditory encoding processes in infants.
Authors 15
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Yuhan Chen corresponding
Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
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Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
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Children's Hospital of Philadelphia · University of Pennsylvania
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia; Department of Radiology, Perelman School of Medicine, University of Pennsylvania;
Department of Radiology, Perelman School of Medicine, University of Pennsylvania
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
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Affiliation as printed
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania;
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania
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Affiliation as printed
Department of Psychiatry, RWTH Aachen University;
Department of Psychiatry, RWTH Aachen University
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Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
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Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
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Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
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Children's Hospital of Philadelphia · University of Pennsylvania
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
-
Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
-
Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
-
Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
-
Children's Hospital of Philadelphia
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia;
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
-
Children's Hospital of Philadelphia · University of Pennsylvania
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia; Department of Radiology, Perelman School of Medicine, University of Pennsylvania;
Department of Radiology, Perelman School of Medicine, University of Pennsylvania
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
-
Children's Hospital of Philadelphia · University of Pennsylvania
Affiliation as printed
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia; Department of Radiology, Perelman School of Medicine, University of Pennsylvania;
Department of Radiology, Perelman School of Medicine, University of Pennsylvania
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia
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