Inborn Errors of Immunity

Springer eBooks, pp. 809–817

Abstract

Abstract Inborn errors of immunity (IEI) comprise diseases arising from genetic defects that lead to abnormalities in immune cell development or function with a wide spectrum in severity and clinical manifestations. The number of transplants for IEI has increased significantly over the last years, elicited by better insight in the pathogenesis of the IEI (and thus the “curability” of these diseases with allo-HCT), better outcomes even with unrelated and haploidentical donors, and more differentiated approaches to HCT including reduced toxicity conditioning regimens.

Authors 4

1. Michael H. Albert corresponding

   Ludwig-Maximilians-Universität München

   Affiliation as printed

   Pediatric SCT Program, Dr. von Hauner University Children’s Hospital, Ludwig-Maximilians Universität, Munich, Germany

   Pediatric SCT Program, Dr. von Hauner University Children's Hospital, Ludwig-Maximilians Universität, Munich, Germany

2. Arjan C. Lankester Aachen Department of Pediatrics, Stem Cell Transplantation Program

   Leiden University Medical Center · Willem-Alexander Kinderziekenhuis

   Affiliation as printed

   Department of Pediatrics, Stem Cell Transplantation Program, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands

   Department of Pediatrics, Stem Cell Transplantation Program, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands

3. Andrew Richard Gennery

   Great North Children's Hospital · Newcastle University

   Affiliation as printed

   Paediatric Immunology + HSCT, Great North Children’s Hospital, Newcastle University, Newcastle upon Tyne, UK

   Paediatric Immunology + HSCT, Great North Children's Hospital, Newcastle University, Newcastle upon Tyne, UK

4. Bénédicte Neven

   Hôpital Necker-Enfants Malades · Assistance Publique – Hôpitaux de Paris

   Affiliation as printed

   Pediatric Immune-Hematology and Rheumatology Unit, Necker Children Hospital, Assistance Publique Hopitaux de Paris, Paris City University, Paris, France