Haploidentical HCT

Springer eBooks, pp. 577–585

Abstract

Abstract We will discuss two platforms of haploidentical HSCT(haplo-HSCT): ex vivo T cell depletion and unmanipulated in vivo T-cell depletion. The former has evolved from positive selection of CD34+ cells to selection of CD34+ cells associated with alpha/beta T cell and CD19 B cell depletion. We will outline the outcome of these procedures in children and adults. More recently selective add back of Treg Tcon has also been developed and will be discussed. The second platform is unmanipulated haplo-HSCT: PTCy and ATG have been used alone or in combination to optimize prevention of GvHD. We will discuss the outcome in patients with hematologic malignancies as well as in patients with non-malignant disorders, such as aplastic anemia, hemoglobinopathies, and immune deficiencies.

Authors 4

1. Andrea Paolo Bacigalupo corresponding

   Università Cattolica del Sacro Cuore · Agostino Gemelli University Polyclinic · Istituti di Ricovero e Cura a Carattere Scientifico

   Affiliation as printed

   Istituto di Ematologia, Fondazione Polclinico Universitario A. Gemelli IRCCS, Universita’ Cattolica del Sacro Cuore, Rome, Italy

   Istituto di Ematologia, Fondazione Polclinico Universitario A. Gemelli IRCCS, Universita' Cattolica del Sacro Cuore, Rome, Italy

2. Arjan C. Lankester Aachen Division of Immunology, Infectious Diseases

   Leiden University Medical Center · Willem-Alexander Kinderziekenhuis

   Affiliation as printed

   Willem-Alexander Children’s Hospital, Division of Immunology, Infectious Diseases, Hematology and Stem Cell Transplantation, Leiden University Medical Center, Leiden, The Netherlands

   Willem-Alexander Children's Hospital, Division of Immunology, Infectious Diseases, Hematology and Stem Cell Transplantation, Leiden University Medical Center, Leiden, The Netherlands

3. Fabio Ciceri

   Vita-Salute San Raffaele University

   Affiliation as printed

   IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy

4. Alice Bertaina

   Stanford Medicine · Stanford University

   Affiliation as printed

   Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA