Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy

Signal Transduction and Targeted Therapy, vol. 8, pp. 339

Abstract

In a recent paper published in Nature , Solier and coworkers showed that a rationally designed dimer of metformin targeting mitochondrial copper content can effectively oppose macrophage activation and plasticity. 1 Since macrophages play critical roles in the initiation and maintenance of inflammation, this drug termed supformin holds promise to be a therapeutic effective in suppressing inflammation-related diseases related to macrophages.

Authors 1

1. Ralf Weiskirchen corresponding Aachen Institute of Molecular Pathobiochemistry Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC)

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Pauwelsstr. 30, D-52074, Aachen, Germany. rweiskirchen@ukaachen.de

   Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Pauwelsstr. 30, D-52074, Aachen, Germany