A
Menu
May 25, 2023 peer-review Open access Aachen paper

Author response: Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

DOI: 10.7554/elife.79565.sa2 Full text (OA) OpenAlex

Abstract

Multimodal spectroscopy (smFRET, EPR, SAXS, and SANS) and integrative structural modeling reveal large-scale domain rearrangements in human guanylate binding protein 1 (hGBP1) that are driving forces for the formation of oligomers that enable its biological function in innate immune defense.

Authors 15

  1. Thomas-Otavio Peulen

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Chair for Molecular Physical Chemistry, Heinrich Heine University Düsseldorf

  2. Carola S. Hengstenberg

    Ruhr University Bochum

    Affiliation as printed

    Physical Chemistry I, Ruhr University Bochum

  3. Ralf Biehl

    Forschungszentrum Jülich

    Affiliation as printed

    Jülich Centre for Neutron Science (JCNS-1) and Institute of Biological Information Processing (IBI-8), Forschungszentrum Jülich GmbH

  4. Mykola Dimura

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Chair for Molecular Physical Chemistry, Heinrich Heine University Düsseldorf

    Institut für Pharmazeutische und Medizinische Chemie, Heinrich Heine University Düsseldorf

  5. Charlotte Lorenz Aachen Institute of Physical Chemistry

    Forschungszentrum Jülich · RWTH Aachen University

    Affiliation as printed

    Institute of Physical Chemistry, RWTH Aachen University

    Jülich Centre for Neutron Science (JCNS-1) and Institute of Biological Information Processing (IBI-8), Forschungszentrum Jülich GmbH

  6. Alessandro Valeri

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Chair for Molecular Physical Chemistry, Heinrich Heine University Düsseldorf

  7. Julian Folz

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Chair for Molecular Physical Chemistry, Heinrich Heine University Düsseldorf

  8. Christian A. Hanke

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Chair for Molecular Physical Chemistry, Heinrich Heine University Düsseldorf

  9. Tobias Vöpel

    Ruhr University Bochum

    Affiliation as printed

    Physical Chemistry I, Ruhr University Bochum

  10. B. Farago

    Institut Laue-Langevin

    Affiliation as printed

    Institut Laue-Langevin

  11. Holger Gohlke

    Forschungszentrum Jülich · Heinrich Heine University Düsseldorf

    Affiliation as printed

    Institut für Pharmazeutische und Medizinische Chemie, Heinrich Heine University Düsseldorf

    Institute of Bio-Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich

  12. Johann P. Klare

    Osnabrück University

    Affiliation as printed

    Macromolecular Structure Group, Department of Physics, University of Osnabrück

  13. Andreas Maximilian Stadler Aachen Institute of Physical Chemistry

    Forschungszentrum Jülich · RWTH Aachen University

    Affiliation as printed

    Institute of Physical Chemistry, RWTH Aachen University

    Jülich Centre for Neutron Science (JCNS-1) and Institute of Biological Information Processing (IBI-8), Forschungszentrum Jülich GmbH

  14. Claus A. M. Seidel

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Chair for Molecular Physical Chemistry, Heinrich Heine University Düsseldorf

  15. Christian Herrmann

    Ruhr University Bochum

    Affiliation as printed

    Physical Chemistry I, Ruhr University Bochum

Cited by 0 stored of 0

No patents citing this paper on Lens.org (checked 2026-10-06).

References 0