A Transformable Mucoadhesive Microgel Network for Noninvasive Multimodal Imaging And Radioprotection of a Large Area of the Gastrointestinal Tract
Advanced Materials, vol. 35, pp. e2303436
Abstract
The lack of noninvasive imaging and modulation of a large area of the gastrointestinal (GI) tract constrain the diagnosis and treatment of many GI-related diseases. Recent advances use novel mucoadhesive materials to coat a part of the GI tract and then modulate its functions. High mucoadhesion is the key factor of the partial coating, but also the limitation for not spreading and covering the lower GI tract. Here, a bismuth-pectin organic-inorganic hybrid complex is screened and engineered into a transformable microgel network (Bi-GLUE) with high flowability and mucoadhesion, such that it can quickly transit through and coat a large area of the GI tract. In murine and porcine models, Bi-GLUE delivers contrast agents to achieve real-time, large-area GI-tract imaging under X-ray or magnetic resonance modalities and to facilitate the non-invasive diagnosis of familial adenomatous polyposis. Moreover, Bi-GLUE, like an intracorporal radiation shield, decreases the radiotoxicity in a whole-abdomen irradiation rat model. This transformable microgel network offers a new direction that can modulate a large area of the GI tract and may have broad applications for GI-related conditions.
Authors 9
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Affiliation as printed
School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030 China
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Affiliation as printed
Advanced Therapies Siemens Healthineers Ltd. Shanghai 200126 China
School of Biomedical Engineering ShanghaiTech University Shanghai 201210 China
Advanced Therapies, Siemens Healthineers Ltd., Shanghai, 200126 China
School of Biomedical Engineering, ShanghaiTech University, Shanghai, 201210 China
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Dongyue Fan Aachen Einthoven Laboratory for Vascular and Regenerative Medicine Division of Thrombosis and Hemostasis Department of Internal Medicine
Leiden University · Shanghai Jiao Tong University · Leiden University Medical Center
Affiliation as printed
Einthoven Laboratory for Vascular and Regenerative Medicine Division of Thrombosis and Hemostasis Department of Internal Medicine Leiden University Medical Center Leiden 2333 ZA Netherlands
School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China
Einthoven Laboratory for Vascular and Regenerative Medicine, Division of Thrombosis and Hemostasis, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2333 ZA Netherlands
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030 China
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Affiliation as printed
School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030 China
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South China University of Technology
Affiliation as printed
South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft Matter South China University of Technology Guangzhou 510640 China
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou, 510640 China
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South China University of Technology
Affiliation as printed
South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft Matter South China University of Technology Guangzhou 510640 China
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou, 510640 China
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Affiliation as printed
School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030 China
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Jie Luo corresponding
Affiliation as printed
School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030 China
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Shiyi Zhang corresponding
Affiliation as printed
School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030 China
Cited by 17 stored of 18
17 results
Cited by patents worldwide 1 (Lens.org)
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HYDROGELS FOR CARGO DELIVERY TO TUBULAR EPITHELIAL STRUCTURESEP4706694A1 2026-03-11 Pending