SINGLE-SESSION BILATERAL REDUCED-SETTINGS PHOTODYNAMIC THERAPY FOR BILATERAL CHRONIC CENTRAL SEROUS CHORIORETINOPATHY
Retina, vol. 43, pp. 1356–1363
Abstract
PURPOSE: We performed a multicenter, retrospective study on patients with bilateral chronic central serous chorioretinopathy (cCSC) who received single-session bilateral reduced-settings photodynamic therapy (ssbPDT) and assessed anatomical (resolution of subretinal fluid [SRF]) and functional (best-corrected visual acuity [BCVA]) outcomes and safety. METHODS: Patients who underwent ssbPDT between 01/01/2011 and 30/09/2022 were included. The resolution of SRF at first, second, and final follow-up was assessed on optical coherence tomography (OCT), and BCVA measurements were collected at these visits. When fovea-involving ssbPDT was performed, ellipsoid zone (EZ) and external limiting membrane (ELM) integrity was graded before and after treatment. RESULTS: Fifty-five patients were included in this study. Sixty-two of hundred and eight eyes (56%) showed a complete resolution of SRF at the first follow-up, which increased to 73/110 (66%) at the final follow-up. The mean logMAR BCVA improved by -0.047 ( P = 0.02) over follow-up. EZ integrity increased from 14/21 (67%) to 24/30 (80%) while ELM integrity increased from 22/30 (73%) to 29/30 (97%). CONCLUSION: Patients with cCSC with bilateral SRF at baseline showed significant anatomical and functional improvements after ssbPDT, both at short-term and long-term follow-up. No relevant adverse events were noted.
Authors 6
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University of Freiburg · University Medical Center Freiburg · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, The Netherlands;
Eye Center, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany;
Department of Ophthalmology,Amsterdam University Medical Centers, Amsterdam, the Netherlands
Eye Center, Medical Center – University of Freiburg,Faculty of Medicine, University of Freiburg, Germany
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Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, The Netherlands;
Department of Ophthalmology,Amsterdam University Medical Centers, Amsterdam, the Netherlands
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Leiden University Medical Center
Affiliation as printed
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands; and
Department of Ophthalmology,Leiden University Medical Center, Leiden, the Netherlands
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Fondation Asile des Aveugles · Amsterdam University Medical Centers · University of Lausanne
Affiliation as printed
Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, The Netherlands;
Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Foundation Asile des Aveugles, Lausanne, Switzerland
Department of Ophthalmology,Amsterdam University Medical Centers, Amsterdam, the Netherlands
Department of Ophthalmology,University of Lausanne, Jules-Gonin Eye Hospital,Foundation Asile des Aveugles, Lausanne, Switzerland
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Leiden University Medical Center
Affiliation as printed
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands; and
Department of Ophthalmology,Leiden University Medical Center, Leiden, the Netherlands
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Camiel J. F. Boon corresponding Aachen Department of Ophthalmology, Leiden University Medical Center
Leiden University Medical Center · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, The Netherlands;
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands; and
Department of Ophthalmology,Amsterdam University Medical Centers, Amsterdam, the Netherlands
Department of Ophthalmology,Leiden University Medical Center, Leiden, the Netherlands
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