Choroidal vascular hyperpermeability patterns in central serous chorioretinopathy correlate with microperimetry: CERTAIN study report 4
Acta Ophthalmologica, vol. 104, pp. 288–295
Abstract
PURPOSE: This report evaluates the association of three distinct leakage patterns of choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA), previously correlated with disease chronicity, with retinal sensitivity measured by microperimetry in central serous chorioretinopathy (CSC): unifocal indistinct signs of hyperpermeability (uni-FISH), multifocal (multi-FISH), and diffuse (DISH). METHODS: The CERTAIN study is a retrospective analysis of consecutive CSC patients referred to a tertiary centre between 01/09/2021 and 30/11/2022. Patients underwent ultra-widefield (UWF) and 55° ICGA plus comprehensive multimodal imaging, including microperimetry. Two independent graders assessed CVH patterns on UWF and 55° ICGA. In case of disagreement, a third grader adjudicated. Eyes with CVH and mesopic microperimetry data were included. RESULTS: In total, 154 eyes from 91 CSC patients were included. On UWF ICGA, DISH showed lower macular sensitivity than the uni-FISH reference (-2.61 dB, p = 0.047). Sensitivity was also lower (-2.24 dB, p = 0.03) when comparing DISH to a combined uni- and multi-FISH group (FISH). On 55° ICGA, DISH again showed lower sensitivity versus uni-FISH (-3.13 dB, p = 0.01) and the FISH group (-2.82 dB, p = 0.010). CONCLUSIONS: The CVH patterns of uni-FISH, multi-FISH, and DISH demonstrate a marked association with levels of retinal sensitivity in CSC patients, particularly macular sensitivity, which is lower in DISH compared to (uni-)FISH. Our findings highlight the potential role of ICGA patterns in assessing disease severity and functional prognostication.
Authors 8
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Jennifer M. Chang‐Wolf Aachen Department of Ophthalmology Leiden University Medical Center Leiden the Netherlands Department of Ophthalmology, Leiden University Medical Center
Leiden University Medical Center · Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology Leiden University Medical Center Leiden The Netherlands
Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, The Netherlands
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
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Amsterdam UMC Location University of Amsterdam · University Medical Center Hamburg-Eppendorf · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology University Medical Center Hamburg‐Eppendorf Hamburg Germany
Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, The Netherlands
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam · Fondation Asile des Aveugles · Amsterdam University Medical Centers · University of Lausanne
Affiliation as printed
Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology University of Lausanne, Jules‐Gonin Eye Hospital, Fondation Asile Des Aveugles Lausanne Switzerland
Ocular Angiogenesis Group Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, The Netherlands
Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile Des Aveugles, Lausanne, Switzerland
Ocular Angiogenesis Group, Amsterdam University Medical Center, Amsterdam, The Netherlands
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Elon H. C. van Dijk Aachen Department of Ophthalmology Leiden University Medical Center Leiden the Netherlands Department of Ophthalmology, Leiden University Medical Center
Leiden University Medical Center · Rotterdam Eye Hospital
Affiliation as printed
Department of Ophthalmology Leiden University Medical Center Leiden The Netherlands
Rotterdam Eye Hospital Rotterdam The Netherlands
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
Rotterdam Eye Hospital, Rotterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, The Netherlands
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Camiel J. F. Boon corresponding Aachen Department of Ophthalmology Leiden University Medical Center Leiden the Netherlands Department of Ophthalmology, Leiden University Medical Center
Leiden University Medical Center · Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers
Affiliation as printed
Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands
Department of Ophthalmology Leiden University Medical Center Leiden The Netherlands
Department of Ophthalmology, Amsterdam University Medical Center, Amsterdam, The Netherlands
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
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