Author response: A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

Abstract

A novel lncRNA marks the Irf8 downstream enhancer that is crucial for differentiation of plasmacytoid dendritic cells (pDC) and classical dendritic cells type 1 (cDC1) and confers feedback inhibition of Irf8 transcription.

Authors 9

1. Huaming Xu Aachen Department of Cell Biology Institute of Biomedical Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cell Biology, Institute of Biomedical Engineering, RWTH Aachen University Medical School

   Helmholtz Institute for Biomedical Engineering, RWTH Aachen University

2. Zhijian Li Aachen Institute for Computational Genomics

   RWTH Aachen University

   Affiliation as printed

   Institute for Computational Genomics, RWTH Aachen University Medical School

3. Chao‐Chung Kuo Aachen Institute for Computational Genomics

   RWTH Aachen University

   Affiliation as printed

   Institute for Computational Genomics, RWTH Aachen University Medical School

4. Katrin Götz Aachen Department of Cell Biology Institute of Biomedical Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cell Biology, Institute of Biomedical Engineering, RWTH Aachen University Medical School

   Helmholtz Institute for Biomedical Engineering, RWTH Aachen University

5. Thomas A. Look Aachen Department of Cell Biology Institute of Biomedical Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cell Biology, Institute of Biomedical Engineering, RWTH Aachen University Medical School

   Helmholtz Institute for Biomedical Engineering, RWTH Aachen University

6. Marcelo AS de Toledo Aachen Department of Cell Biology Institute of Biomedical Engineering Department of Hematology, Oncology Faculty of Medicine

   RWTH Aachen University

   Affiliation as printed

   Department of Cell Biology, Institute of Biomedical Engineering, RWTH Aachen University Medical School

   Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University

   Helmholtz Institute for Biomedical Engineering, RWTH Aachen University

7. Kristin Seré Aachen Department of Cell Biology Institute of Biomedical Engineering

   RWTH Aachen University

   Affiliation as printed

   Department of Cell Biology, Institute of Biomedical Engineering, RWTH Aachen University Medical School

   Helmholtz Institute for Biomedical Engineering, RWTH Aachen University

8. Ivan G. Costa Aachen Institute for Computational Genomics

   RWTH Aachen University

   Affiliation as printed

   Institute for Computational Genomics, RWTH Aachen University Medical School

9. Martin Zenke Aachen Department of Cell Biology Institute of Biomedical Engineering Department of Hematology, Oncology Faculty of Medicine

   RWTH Aachen University

   Affiliation as printed

   Department of Cell Biology, Institute of Biomedical Engineering, RWTH Aachen University Medical School

   Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University

   Helmholtz Institute for Biomedical Engineering, RWTH Aachen University