Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
Antibiotics, vol. 12, pp. 455
Abstract
(MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiotics. Persistent MRSA bacteremia is common and is associated with poor clinical outcomes. The etiology of persistent MRSA bacteremia is a result of the complex interplay between the host, the pathogen, and the antibiotic used to treat the infection. In this review, we explore the factors related to each component of the host-pathogen interaction and discuss the clinical relevance of each element. Next, we discuss the treatment options and diagnostic approaches for the management of persistent MRSA bacteremia.
Authors 4
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University of North Carolina at Chapel Hill · Duke University · Duke Medical Center
Affiliation as printed
Department of Medicine, Division of Infectious Disease, Duke University Medical Center, Durham, NC 27710, USA
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
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Duke University · Leiden University Medical Center · Duke Medical Center
Affiliation as printed
Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
Department of Medicine, Division of Infectious Disease, Duke University Medical Center, Durham, NC 27710, USA
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University of North Carolina at Chapel Hill
Affiliation as printed
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
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Vance G. Fowler corresponding
Duke University · Duke Medical Center
Affiliation as printed
Department of Medicine, Division of Infectious Disease, Duke University Medical Center, Durham, NC 27710, USA
Duke Clinical Research Institute, Durham, NC 27710, USA
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