Novel Size-Variable Dedicated Rodent Oxygenator for ECLS Animal Models: Introduction of the “Ratox” Oxygenator and Preliminary In-Vitro Results
Abstract
The survival rate of extracorporeal life support (ECLS) remains overall at 60 %. Research and development is slow, partly due to the lack of sophisticated experimental models. This publication introduces a dedicated rodent oxygenator (“RatOx”) and shows preliminary in vitro classification tests. The RatOx has an adaptable fiber module size for various rodent models. Gas transfer performance over the fiber module for different blood flows and fiber module sizes were tested according to DIN EN ISO 7199.At the maximum possible amount of effective fiber surface and a blood flow of 100 ml/min, the oxygenator performance has been tested to a maximum of 6.27 ml O2/min and 8.2 ml CO2/min, respectively. The priming volume for this the largest fiber module is 5.4 ml, while the smallest possible configuration with a single fiber mat layer has 1.1 ml of priming volume. The novel RatOx ECLS system has been evaluated in-vitro to comply to a high degree with all predefined functionality criteria for rodent sized animal models. We intend for the RatOx to become a standard testing platform for scientific studies on ECLS therapy and technology.
Authors 12
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Lasse J. Strudthoff corresponding Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Jannis Focke Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Felix Hesselmann Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Andreas Kaesler Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Department of Biomechanical Engineering , Faculty of Engineering Technologies , University of Twente , 7522 LW Enschede , The Netherlands
Department of Biomechanical Engineering , Faculty of Engineering Technologies , University of Twente , 7522 LW Enschede , The Netherlands ;
Department of Biomechanical Engineering, Faculty of Engineering Technologies, University of Twente, 7522 LW Enschede, The Netherlands
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Peter Schlanstein Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , Aachen , Germany
Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , Aachen , Germany;
Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany
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Ulrich Steinseifer Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Niklas B. Steuer Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Medizinische Hochschule Hannover · German Center for Lung Research
Affiliation as printed
Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School
German Center for Lung Research (DLZ), Hanover, Germany
Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Hanover, Germany
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Jutta Arens Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
RWTH Aachen University · University of Twente
Affiliation as printed
Department of Biomechanical Engineering , Faculty of Engineering Technologies , University of Twente , 7522 LW Enschede , The Netherlands
Department of Biomechanical Engineering , Faculty of Engineering Technologies , University of Twente , 7522 LW Enschede , The Netherlands ;
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Biomechanical Engineering, Faculty of Engineering Technologies, University of Twente, 7522 LW Enschede, The Netherlands
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Sebastian Victor Jansen Aachen Department of Cardiovascular Engineering Institute of Applied Medical Engineering Medical Faculty
Affiliation as printed
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany
Department of Cardiovascular Engineering , Institute of Applied Medical Engineering , Medical Faculty , RWTH Aachen University , 52074 Aachen , Germany;
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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