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December 26, 2022 article Open access Aachen paper

Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19

iScience, vol. 26, pp. 105873

DOI: 10.1016/j.isci.2022.105873 Full text (OA) OpenAlex

Abstract

infected individuals (LTBI), and from COVID-19 patients and healthy controls. Analysis of host proteins showed significantly lower levels in LTBI versus TB (AUC:0 · 94) and discriminated healthy individuals from COVID-19 patients (0 · 99) and severe COVID-19 from TB. Importantly, these host proteins allowed treatment monitoring of both respiratory diseases. This study demonstrates the potential of non-sputum LF assays as adjunct diagnostics and treatment monitoring for COVID-19 and TB based on quantitative detection of multiple host biomarkers.

Authors 49

  1. Louise Pierneef Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  2. Anouk van Hooij Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  3. Daniëlle de Jong Aachen Department of Cell and Chemical Biology

    Leiden University Medical Center

    Affiliation as printed

    Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands

  4. Elisa M. Tjon Kon Fat Aachen Department of Cell and Chemical Biology

    Leiden University Medical Center

    Affiliation as printed

    Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands

  5. Krista E. van Meijgaarden Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  6. Elisa Petruccioli

    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

    Affiliation as printed

    National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy

  7. Valentina Vanini

    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

    Affiliation as printed

    National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy

  8. Anna H.E. Roukens Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  9. Delia Goletti

    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

    Affiliation as printed

    National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy

  10. Paul L. A. M. Corstjens Aachen Department of Cell and Chemical Biology

    Leiden University Medical Center

    Affiliation as printed

    Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands

  11. Simone A. Joosten Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  12. Annemieke Geluk corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  13. M. Sesmu Arbous
  14. Bernard M. van den Berg
  15. Suzanne C. Cannegieter Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  16. Christa M. Cobbaert
  17. Anne M. van der Does
  18. Jacques J. M. van Dongen
  19. Jeroen C.J. Eikenboom Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  20. M.C.M. Feltkamp
  21. Jelle J. Goeman
  22. Martin A. Giera corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  23. Thomas Hankemeier Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  24. Mirjam H.M. Heemskerk
  25. Pieter Sicco Hiemstra
  26. Cornelis Hendrik Hokke
  27. Jacqueline J. Janse
  28. Simon P. Jochems
  29. Marjolein Kikkert corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  30. Lieke Lamont corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  31. Judith Manniën Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  32. Tom H. M. Ottenhoff
  33. N. Queralt Rosinach corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  34. Meta Roestenberg corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  35. Marco Roos corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  36. Hermelijn H. Smits
  37. Eric J. Snijder Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  38. Frank J. T. Staal
  39. Leendert Adrianus Trouw Aachen Department of Cell and Chemical Biology

    Leiden University Medical Center

    Affiliation as printed

    Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands

  40. Roula Tsonaka Aachen Department of Cell and Chemical Biology

    Leiden University Medical Center

    Affiliation as printed

    Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands

  41. Aswin Verhoeven
  42. Leo G. Visser
  43. Jutte J.C. de Vries
  44. David J. van Westerloo
  45. Jeanette Wigbers Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  46. Robin C. van Wissen
  47. Manfred Wuhrer corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  48. Maria Yazdanbakhsh corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

  49. Mihaela Zlei corresponding Aachen Department of Infectious Diseases

    Leiden University Medical Center

    Affiliation as printed

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands

Cited by 17 stored of 16

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Cited by patents worldwide 2 (Lens.org)

References 94