Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation

Angewandte Chemie International Edition, vol. 62, pp. e202215678

Abstract

Abstract The feasibility of Carbon‐13 Radiofrequency (RF) Amplification by Stimulated Emission of Radiation (C‐13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl [1‐13C]acetate. Hyperpolarized ethyl [1‐13C]acetate was prepared via pairwise addition of parahydrogen to vinyl [1‐13C]acetate and polarization transfer from nascent parahydrogen‐derived protons to the carbon‐13 nucleus via magnetic field cycling yielding C‐13 nuclear spin polarization of approximately 6 %. RASER signals were detected from samples with concentration ranging from 0.12 to 1 M concentration using a non‐cryogenic 1.4T NMR spectrometer equipped with a radio‐frequency detection coil with a quality factor (Q) of 32 without any modifications. C‐13 RASER signals were observed for several minutes on a single bolus of hyperpolarized substrate to achieve 21 mHz NMR linewidths. The feasibility of creating long‐lasting C‐13 RASER on biomolecular carriers opens a wide range of new opportunities for the rapidly expanding field of C‐13 magnetic resonance hyperpolarization.

Authors 11

1. Christopher D. Nelson

   North Carolina State University

   Affiliation as printed

   Department of Chemistry North Carolina State University 27695-8204 Raleigh, NC USA

2. Andreas Benjamin Schmidt

   German Cancer Research Center · University of Freiburg · University Medical Center Freiburg · Deutsches Konsortium für Translationale Krebsforschung · Wayne State University · The Barbara Ann Karmanos Cancer Institute

   Affiliation as printed

   Department of Chemistry Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI) Wayne State University 48202 Detroit, MI USA

   Division of Medical Physics Department of Radiology Medical Center Faculty of Medicine University of Freiburg Killianstr. 5a 79106 Freiburg Germany

   German Cancer Consortium (DKTK) partner site Freiburg and German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Germany

3. Isaiah Olabisi Adelabu

   Wayne State University · The Barbara Ann Karmanos Cancer Institute

   Affiliation as printed

   Department of Chemistry Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI) Wayne State University 48202 Detroit, MI USA

4. Shiraz Nantogma

   Wayne State University · The Barbara Ann Karmanos Cancer Institute

   Affiliation as printed

   Department of Chemistry Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI) Wayne State University 48202 Detroit, MI USA

5. Valerij G. Kiselev

   German Cancer Research Center · University of Freiburg · University Medical Center Freiburg · Deutsches Konsortium für Translationale Krebsforschung

   Affiliation as printed

   Division of Medical Physics Department of Radiology Medical Center Faculty of Medicine University of Freiburg Killianstr. 5a 79106 Freiburg Germany

   German Cancer Consortium (DKTK) partner site Freiburg and German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Germany

6. Abubakar Abdurraheem

   Wayne State University · The Barbara Ann Karmanos Cancer Institute

   Affiliation as printed

   Department of Chemistry Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI) Wayne State University 48202 Detroit, MI USA

7. Henri de Maissin

   German Cancer Research Center · University of Freiburg · University Medical Center Freiburg · Deutsches Konsortium für Translationale Krebsforschung

   Affiliation as printed

   Division of Medical Physics Department of Radiology Medical Center Faculty of Medicine University of Freiburg Killianstr. 5a 79106 Freiburg Germany

   German Cancer Consortium (DKTK) partner site Freiburg and German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Germany

8. Sören Lehmkuhl

   Karlsruhe Institute of Technology

   Affiliation as printed

   Institute of Microstructure Technology Karlsruhe Institute of Technology Eggenstein-Leopoldshafen 76344 Karlsruhe Germany

9. Stephan Appelt Aachen Institute of Technical and Macromolecular Chemistry

   RWTH Aachen University · Forschungszentrum Jülich

   Affiliation as printed

   Central Institute for Engineering, Electronics and Analytics— Electronic Systems (ZEA-2) Forschungszentrum Jülich GmbH 52425 Jülich Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University 52056 Aachen Germany

10. Thomas Theis corresponding

    North Carolina State University

    Affiliation as printed

    Department of Chemistry North Carolina State University 27695-8204 Raleigh, NC USA

11. Eduard Y. Chekmenev corresponding

    Russian Academy of Sciences · Wayne State University · The Barbara Ann Karmanos Cancer Institute

    Affiliation as printed

    Department of Chemistry Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI) Wayne State University 48202 Detroit, MI USA

    Russian Academy of Sciences (RAS) 14 Leninskiy Prospekt 119991 Moscow Russia